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10.1016/j.jneuroim.2020.577323

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suck abstract from ncbi


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pmid32688146
      J+Neuroimmunol 2020 ; 346 (ä): 577323
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  • The peripheral blood immune cell profile in a teriflunomide-treated multiple sclerosis patient with COVID-19 pneumonia #MMPMID32688146
  • Ciardi MR ; Zingaropoli MA ; Pasculli P ; Perri V ; Tartaglia M ; Valeri S ; Russo G ; Conte A ; Mastroianni CM
  • J Neuroimmunol 2020[Sep]; 346 (ä): 577323 PMID32688146 show ga
  • A teriflunomide-treated multiple sclerosis patient with COVID-19 pneumonia was hospitalized and recovered in 15 days. The immunophenotyping analysis of peripheral blood cells was performed in two time points: the first was 1 month before (pre-infection) while the second was during COVID-19 pneumonia (infection). At the infection time point, no differences in the percentages of immune activation and immunesenescence of CD4+ and CD8+ T-cells were observed compared to the pre-infection time point. Our evaluation seems to confirm that teriflunomide controls T-cells immune activation and immunosenescence suggesting that teriflunomide should not be discontinued in MS patients with an active COVID-19 pneumonia.
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