Transcription Factor Nrf2 as a Potential Therapeutic Target for Prevention of
Cytokine Storm in COVID-19 Patients
#MMPMID33040727
Zinovkin RA
; Grebenchikov OA
Biochemistry (Mosc)
2020[Jul]; 85
(7
): 833-837
PMID33040727
show ga
Nrf2 is a key transcription factor responsible for antioxidant defense in many
tissues and cells, including alveolar epithelium, endothelium, and macrophages.
Furthermore, Nrf2 functions as a transcriptional repressor that inhibits
expression of the inflammatory cytokines in macrophages. Critically ill patients
with COVID-19 infection often present signs of high oxidative stress and systemic
inflammation - the leading causes of mortality. This article suggests rationale
for the use of Nrf2 inducers to prevent development of an excessive inflammatory
response in COVID-19 patients.
|*Betacoronavirus
[MESH]
|Animals
[MESH]
|Antioxidants/pharmacology/therapeutic use
[MESH]
|COVID-19
[MESH]
|COVID-19 Drug Treatment
[MESH]
|Catechin/analogs & derivatives/pharmacology/therapeutic use
[MESH]
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