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10.1016/j.cell.2020.06.044 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.06.044 C7355337!7355337 !32673567     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32673567 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell 2020 ; 182 (4 ): 843-854.e12 Nephropedia Template TP {{tp|p=32673567 |t=2020. Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients |pdf=|usr=}}{{32673567 }} gab.com Text Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=32673567 #FOAvip The SARS-CoV-2 pandemic has unprecedented implications for public health, social life, and the world economy. Because approved drugs and vaccines are limited or not available, new options for COVID-19 treatment and prevention are in high demand. To identify SARS-CoV-2-neutralizing antibodies, we analyzed the antibody response of 12 COVID-19 patients from 8 to 69 days after diagnosis. By screening 4,313 SARS-CoV-2-reactive B cells, we isolated 255 antibodies from different time points as early as 8 days after diagnosis. Of these, 28 potently neutralized authentic SARS-CoV-2 with IC(100) as low as 0.04 ?g/mL, showing a broad spectrum of variable (V) genes and low levels of somatic mutations. Interestingly, potential precursor sequences were identified in naive B cell repertoires from 48 healthy individuals who were sampled before the COVID-19 pandemic. Our results demonstrate that SARS-CoV-2-neutralizing antibodies are readily generated from a diverse pool of precursors, fostering hope for rapid induction of a protective immune response upon vaccination. Twit Text FOAVip Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=32673567 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32673567 #FOAvip English Wikipedia <ref>{{Cite pmid|32673567 }}</ref> Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients #MMPMID32673567 Kreer C ; Zehner M ; Weber T ; Ercanoglu MS ; Gieselmann L ; Rohde C ; Halwe S ; Korenkov M ; Schommers P ; Vanshylla K ; Di Cristanziano V ; Janicki H ; Brinker R ; Ashurov A ; Krähling V ; Kupke A ; Cohen-Dvashi H ; Koch M ; Eckert JM ; Lederer S ; Pfeifer N ; Wolf T ; Vehreschild MJGT ; Wendtner C ; Diskin R ; Gruell H ; Becker S ; Klein F Cell 2020[Aug]; 182 (4 ): 843-854.e12 PMID32673567 show ga The SARS-CoV-2 pandemic has unprecedented implications for public health, social life, and the world economy. Because approved drugs and vaccines are limited or not available, new options for COVID-19 treatment and prevention are in high demand. To identify SARS-CoV-2-neutralizing antibodies, we analyzed the antibody response of 12 COVID-19 patients from 8 to 69 days after diagnosis. By screening 4,313 SARS-CoV-2-reactive B cells, we isolated 255 antibodies from different time points as early as 8 days after diagnosis. Of these, 28 potently neutralized authentic SARS-CoV-2 with IC(100) as low as 0.04 ?g/mL, showing a broad spectrum of variable (V) genes and low levels of somatic mutations. Interestingly, potential precursor sequences were identified in naive B cell repertoires from 48 healthy individuals who were sampled before the COVID-19 pandemic. Our results demonstrate that SARS-CoV-2-neutralizing antibodies are readily generated from a diverse pool of precursors, fostering hope for rapid induction of a protective immune response upon vaccination. |Antibodies, Neutralizing/genetics/immunology/*isolation & purification [MESH] |Antibodies, Viral/genetics/immunology/*isolation & purification [MESH] |B-Lymphocytes/immunology [MESH] |Betacoronavirus/immunology [MESH] |COVID-19 [MESH] |Coronavirus Infections/*immunology [MESH] |Humans [MESH] |Immunoglobulin Variable Region/genetics/immunology [MESH] |Immunologic Memory [MESH] |Longitudinal Studies [MESH] |Pandemics [MESH] |Pneumonia, Viral/*immunology [MESH] |SARS-CoV-2 [MESH]Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing(epmc).pdf DeepDyve Pubget Overpricing