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Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Diagn+Microbiol+Infect+Dis 2020 ; 98 (3): 115140 Nephropedia Template TP
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Monitoring antibody response following SARS-CoV-2 infection: diagnostic efficiency of 4 automated immunoassays #MMPMID32829098
Wolff F; Dahma H; Duterme C; Van den Wijngaert S; Vandenberg O; Cotton F; Montesinos I
Diagn Microbiol Infect Dis 2020[Nov]; 98 (3): 115140 PMID32829098show ga
Introduction: SARS-CoV-2 seroconversion is important for epidemiological studies as well as contact tracing. Material and methods: The antibody response against SARS-CoV-2 was examined in 111 patients with a positive qRT-PCR. Seroconversion was assessed using the Elecsys from Roche, the Liaison S1/S2 IgG from Diasorin, the IgG and IgA from Euroimmun, as well as the VIDAS IgG and IgM. Specificity was estimated based on the measurement of SARS-CoV-2 antibodies in 96 residual samples collected during a non-pandemic period. Results: The highest overall sensitivity for detecting seroconversion was obtained using the Elecsys (81.1%), the Euroimmun with a combined detection of IgG/IgA (86.5%), and the VIDAS with a simultaneous measurement of IgG/IgM (78.4%).The Elecsys and the VIDAS IgG/IgM demonstrated a specificity as well as a positive predictive value of 100%. Conclusions: The Elecsys and the VIDAS methods with a combination of IgG/IgM measurement demonstrated a high sensitivity with no false positive results.