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Involvement of Spike Protein, Furin, and ACE2 in SARS-CoV-2-Related
Cardiovascular Complications
#MMPMID32838164
Ming Y
; Qiang L
SN Compr Clin Med
2020[]; 2
(8
): 1103-1108
PMID32838164
show ga
The novel coronavirus disease 2019 (COVID-19) is a global epidemic caused by
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). SARS-CoV-2 has a
similar structure to severe acute respiratory syndrome coronavirus-1(SARS-CoV-1).
The S protein on the surface of the virus is cleaved by host proprotein
convertases (PCs) to expose the active N-terminal S1 extracellular domain. Its
receptors are angiotensin-converting enzyme 2 (ACE2), and the C-terminal S2
membrane anchoring protein is responsible for translocating the virus into the
cell. Among patients with COVID-19, there is a higher prevalence of
cardiovascular disease, and more than 7% of patients have suffered myocardial
damage due to the infection, but the internal mechanism is still poorly
understood. There is currently no specific and effective targeted treatment.
Reduction of the patient's morbidity and mortality is an urgent problem that
needs to be solved clinically. By exploring the theoretical analysis of PCs and
ACE2 in COVID-19 cardiovascular susceptibility, some insights on how to prevent
and alleviate adverse cardiovascular prognosis have been provided in this study.
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