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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Eur+J+Clin+Microbiol+Infect+Dis 2020 ; 39 (12): 2279-87 Nephropedia Template TP
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Clinical features in 52 patients with COVID-19 who have increased leukocyte count: a retrospective analysis #MMPMID32651736
Zhao K; Li R; Wu X; Zhao Y; Wang T; Zheng Z; Zeng S; Ding X; Nie H
Recent reports have showed that a proportion of patients with Coronavirus Disease 2019 (COVID-19) presented elevated leukocyte count. Clinical data about these patients is scarce. We aimed to evaluate the clinical findings of patients with COVID-19 who have increased leukocyte at admission. We retrospectively collected the clinical data on the 52 patients who have increased leukocyte count at admission from the 619 patients with confirmed COVID-19 who had pneumonia with abnormal features on chest CT scan in Renmin Hospital of Wuhan University in Wuhan, China, from February 3 to March 3, 2020. The mean age of the 52 patients with increased leukocyte count was 64.7 (SD 11.4) years, 32 (61.5%) were men and 47 (90.4%) had fever. Compared with the patients with non-increased leukocyte count, the patients with increased leukocyte count were significantly older (P?0.01), were more likely to have underlying chronic diseases (P?0.01), more likely to develop critically illness (P?0.01), more likely to admit to an ICU (P?0.01), more likely to receive mechanical ventilation (P?0.01), had higher rate of death (P?0.01) and the blood levels of neutrophil count and the serum concentrations of CRP and IL-6 were significantly increased, (P?0.01). The older patients with COVID-19 who had underlying chronic disorders are more likely to develop leukocytosis. These patients are more likely to develop critical illness, with a high admission to an ICU and a high mortality rate.