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2020 ; 39
(12
): 2279-2287
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Clinical features in 52 patients with COVID-19 who have increased leukocyte
count: a retrospective analysis
#MMPMID32651736
Zhao K
; Li R
; Wu X
; Zhao Y
; Wang T
; Zheng Z
; Zeng S
; Ding X
; Nie H
Eur J Clin Microbiol Infect Dis
2020[Dec]; 39
(12
): 2279-2287
PMID32651736
show ga
Recent reports have showed that a proportion of patients with Coronavirus Disease
2019 (COVID-19) presented elevated leukocyte count. Clinical data about these
patients is scarce. We aimed to evaluate the clinical findings of patients with
COVID-19 who have increased leukocyte at admission. We retrospectively collected
the clinical data on the 52 patients who have increased leukocyte count at
admission from the 619 patients with confirmed COVID-19 who had pneumonia with
abnormal features on chest CT scan in Renmin Hospital of Wuhan University in
Wuhan, China, from February 3 to March 3, 2020. The mean age of the 52 patients
with increased leukocyte count was 64.7 (SD 11.4) years, 32 (61.5%) were men and
47 (90.4%) had fever. Compared with the patients with non-increased leukocyte
count, the patients with increased leukocyte count were significantly older
(P?0.01), were more likely to have underlying chronic diseases (P?0.01), more
likely to develop critically illness (P?0.01), more likely to admit to an ICU
(P?0.01), more likely to receive mechanical ventilation (P?0.01), had higher
rate of death (P?0.01) and the blood levels of neutrophil count and the serum
concentrations of CRP and IL-6 were significantly increased, (P?0.01). The
older patients with COVID-19 who had underlying chronic disorders are more likely
to develop leukocytosis. These patients are more likely to develop critical
illness, with a high admission to an ICU and a high mortality rate.