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10.1007/s42399-020-00392-z

http://scihub22266oqcxt.onion/10.1007/s42399-020-00392-z
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C7351559!7351559!32838163
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suck abstract from ncbi


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pmid32838163      SN+Compr+Clin+Med 2020 ; 2 (8): 1057-63
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  • Can HCQ Be Considered a ?Safe Weapon? for COVID-19 in the Indian Population? #MMPMID32838163
  • Thangaraju P; Venkatesan N; Venkatesan S; Gurunthalingam MP; Thangaraju E
  • SN Compr Clin Med 2020[]; 2 (8): 1057-63 PMID32838163show ga
  • With no drugs currently approved for treatment and cure of COVID-19 (coronavirus disease 2019), hydroxychloroquine is one of the many first-line drugs used in the management. However, given the life-threatening adverse effects of HCQ that have been reported, its use as a prophylactic treatment remains debated. HCQ has long been used in India for the treatment of malaria, auto-immune and inflammatory diseases, and even type 2 diabetes mellitus recently. We aimed to review existing literature and relevant Web sites regarding the safety profile of HCQ in the Indian subcontinent. A non-systematic critical analysis of all published literature/studies focused on the Indian population, recording on the use of HCQ for various indications up till April 2020 was done and frequency of occurrence of HCQ related life-threatening and cardiac side effects were noted. Results from PubMed database showed an incidence of 0.6% of cardiac-related side effects and 7.42% of other self-limiting and minor side effects among the Indian population on HCQ. Considering its minimal risk and favorable safety profile, cost-effectiveness, availability, and affordability in India, the use of hydroxychloroquine in the fight against COVID-19 appears rationale. Following the results of our study, we hypothesize that Indians might be less likely to suffer from cardiac-related side effects given their genetic make-up. However, this would need further studies, clinical trials, and a pharmacogenomic understanding of the subject.
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