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2020 ; 226
(ä): 38-45
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Intermittent fasting, a possible priming tool for host defense against SARS-CoV-2
infection: Crosstalk among calorie restriction, autophagy and immune response
#MMPMID32659267
Hannan MA
; Rahman MA
; Rahman MS
; Sohag AAM
; Dash R
; Hossain KS
; Farjana M
; Uddin MJ
Immunol Lett
2020[Oct]; 226
(ä): 38-45
PMID32659267
show ga
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative
pathogen of deadly Coronavirus disease-19 (COVID-19) pandemic, which emerged as a
major threat to public health across the world. Although there is no clear gender
or socioeconomic discrimination in the incidence of COVID-19, individuals who are
older adults and/or with comorbidities and compromised immunity have a relatively
higher risk of contracting this disease. Since no specific drug has yet been
discovered, strengthening immunity along with maintaining a healthy living is the
best way to survive this disease. As a healthy practice, calorie restriction in
the form of intermittent fasting (IF) in several clinical settings has been
reported to promote several health benefits, including priming of the immune
response. This dietary restriction also activates autophagy, a cell surveillance
system that boosts up immunity. With these prevailing significance in priming
host defense, IF could be a potential strategy amid this outbreak to fighting off
SARS-CoV-2 infection. Currently, no review so far available proposing IF as an
encouraging strategy in the prevention of COVID-19. A comprehensive review has
therefore been planned to highlight the beneficial role of fasting in immunity
and autophagy, that underlie the possible defense against SARS-CoV-2 infection.
The COVID-19 pathogenesis and its impact on host immune response have also been
briefly outlined. This review aimed at revisiting the immunomodulatory potential
of IF that may constitute a promising preventive approach against COVID-19.