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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Intern+Emerg+Med 2020 ; 15 (8): 1399-407 Nephropedia Template TP
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Impact of COVID-19 on liver function: results from an internal medicine unit in Northern Italy #MMPMID32651938
Lenti MV; Borrelli de Andreis F; Pellegrino I; Klersy C; Merli S; Miceli E; Aronico N; Mengoli C; Di Stefano M; Cococcia S; Santacroce G; Soriano S; Melazzini F; Delliponti M; Baldanti F; Triarico A; Corazza GR; Pinzani M; Di Sabatino A
Intern Emerg Med 2020[]; 15 (8): 1399-407 PMID32651938show ga
Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function in 100 COVID-19 consecutive patients (median age 70 years, range 25?97; 79 males) who were admitted to our internal medicine unit in March 2020. We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome. A patient was considered as having liver injury when alanine aminotransferase (ALT) was?>?50 mU/ml, gamma-glutamyl transpeptidase (GGT)?>?50 mU/ml, or total bilirubin?>?1.1 mg/dl. Spearman correlation coefficient for laboratory data and bivariable analysis for mortality and/or need for intensive care were assessed. A minority of patients (18.6%) were obese, and most patients were non- or moderate-drinkers (88.5%). Liver function tests were altered in 62.4% of patients, and improved during follow-up. None of the seven patients with known chronic liver disease had liver decompensation. Only one patient developed acute liver failure. In patients with altered liver function tests, PaO2/FiO2?200 was associated with greater mortality and need for intensive care (HR 2.34, 95% CI 1.07?5.11, p?=?0.033). To conclude, a high prevalence of altered liver function tests was noticed in Italian patients with COVID-19, and this was associated with worse outcomes when developing severe acute respiratory distress syndrome.Electronic supplementary material: The online version of this article (10.1007/s11739-020-02425-w) contains supplementary material, which is available to authorized users.