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2020 ; 56
(4
): 106093
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gab.com Text
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Adaptation of a Russian population to SARS-CoV-2: Asymptomatic course,
comorbidities, mortality, and other respiratory viruses - A reply to Fear versus
Data
#MMPMID32653618
Sharov KS
Int J Antimicrob Agents
2020[Oct]; 56
(4
): 106093
PMID32653618
show ga
This study was conducted to assess the spread of SARS-CoV-2 in Russia and the
adaptation of the population to the virus in March to June 2020. Two groups were
investigated: 1) 12 082 individuals already proven positive for SARS-CoV-2
(clinical information was studied); 2) 7864+4458 individuals with suspected
respiratory infections (polymerase chain reaction [PCR] tests and clinical
information were studied). In the latter, SARS-CoV-2-positive individuals
comprised 5.37% in March and 11.42% in June 2020. Several viral co-infections
were observed for SARS-CoV-2. Rhinoviruses accounted for the largest proportion
of co-infections (7.91% of samples were SARS-CoV-2-positive); followed by
respiratory syncytial virus (7.03%); adenoviruses (4.84%); metapneumoviruses
(3.29%); parainfluenza viruses (2.42%); enterovirus D68 (1.10%) and other viruses
(entero-, echo-, parecho-) (<1%). Average SARS-CoV-2 case fatality rate in the
group of 12 537 individuals was determined to be 0.6% (in contrast to official
Russian government statistics of 1.5% mortality). This rate is within the range
of mortality caused by other common seasonal respiratory viruses (0.01-2.21% in
Russia in 2012 to 2020). Most fatalities occurred in individuals with
comorbidities, as for other respiratory viruses. The proportion of SARS-CoV-2
asymptomatic carriers was 56.68% in March and 70.67% in June 2020. This new
pathogen presents a substantial risk to human beings as it was not contained at
the start of its outbreak in Wuhan and spread worldwide. However, surveillance,
prevention and treatment must be strictly evidence-based and not dictated by
fear.