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10.1016/j.lfs.2020.118075 http://scihub22266oqcxt.onion/10.1016/j.lfs.2020.118075 C7347488!7347488 !32653522     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32653522 &cmd=llinks): Failed to open stream: HTTP request failed! 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The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions |pdf=|usr=}}{{32653522 }} gab.com Text The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions JO: Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=32653522 #FOAvip The novel corona virus disease has shaken the entire world with its deadly effects and rapid transmission rates, posing a significant challenge to the healthcare authorities to develop suitable therapeutic solution to save lives on earth. The review aims to grab the attention of the researchers all over the globe, towards the role of ACE2 in COVID-19 disease. ACE2 serves as a molecular target for the SARS-CoV-2, to enter the target cell, by interacting with the viral glycoprotein spikes. However, the complexity began when numerous studies identified the protective response of ACE2 in abbreviating the harmful effects of vasoconstrictor, anti-inflammatory peptide, angiotensin 2, by mediating its conversion to angiotensin-(1-7), which exercised antagonistic actions to angiotensin 2. Furthermore, certain investigations revealed greater resistance among children as compared to the geriatrics, towards COVID-19 infection, despite the elevated expression of ACE2 in pediatric population. Based upon such evidences, the review demonstrated possible therapeutic interventions, targeting both the protective and deleterious effects of ACE2 in COVID-19 disease, primarily inhibiting ACE2-virus interactions or administering soluble ACE2. Thus, the authors aim to provide an opportunity for the researchers to consider RAAS system to be a significant element in development of suitable treatment regime for COVID-19 pandemic. Twit Text FOAVip The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions ????Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=32653522 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32653522 #FOAvip English Wikipedia <ref>{{Cite pmid|32653522 }}</ref> The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions #MMPMID32653522 Behl T ; Kaur I ; Bungau S ; Kumar A ; Uddin MS ; Kumar C ; Pal G ; Sahil ; Shrivastava K ; Zengin G ; Arora S Life Sci 2020[Sep]; 257 (ä): 118075 PMID32653522 show ga The novel corona virus disease has shaken the entire world with its deadly effects and rapid transmission rates, posing a significant challenge to the healthcare authorities to develop suitable therapeutic solution to save lives on earth. The review aims to grab the attention of the researchers all over the globe, towards the role of ACE2 in COVID-19 disease. ACE2 serves as a molecular target for the SARS-CoV-2, to enter the target cell, by interacting with the viral glycoprotein spikes. However, the complexity began when numerous studies identified the protective response of ACE2 in abbreviating the harmful effects of vasoconstrictor, anti-inflammatory peptide, angiotensin 2, by mediating its conversion to angiotensin-(1-7), which exercised antagonistic actions to angiotensin 2. Furthermore, certain investigations revealed greater resistance among children as compared to the geriatrics, towards COVID-19 infection, despite the elevated expression of ACE2 in pediatric population. Based upon such evidences, the review demonstrated possible therapeutic interventions, targeting both the protective and deleterious effects of ACE2 in COVID-19 disease, primarily inhibiting ACE2-virus interactions or administering soluble ACE2. Thus, the authors aim to provide an opportunity for the researchers to consider RAAS system to be a significant element in development of suitable treatment regime for COVID-19 pandemic. |Age Factors [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Angiotensin-Converting Enzyme 2 [MESH] |Anti-Inflammatory Agents/pharmacology [MESH] |Betacoronavirus/immunology/pathogenicity [MESH] |COVID-19 [MESH] |Child [MESH] |Child, Preschool [MESH] |Coronavirus Infections/epidemiology/immunology/pathology/*therapy [MESH] |Coronavirus/immunology/pathogenicity [MESH] |Female [MESH] |Geriatrics [MESH] |Humans [MESH] |Infant [MESH] |Infant, Newborn [MESH] |Male [MESH] |Pandemics [MESH] |Pediatrics [MESH] |Peptidyl-Dipeptidase A/*metabolism [MESH] |Pneumonia, Viral/epidemiology/immunology/pathology/*therapy [MESH] |Protein Binding [MESH] |Receptors, Virus/metabolism [MESH] |Renin-Angiotensin System [MESH] |SARS-CoV-2 [MESH] |Severe Acute Respiratory Syndrome/epidemiology/virology [MESH]The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics(epmc).pdf DeepDyve Pubget Overpricing