Potential influence of Nagella sativa (Black cumin) in reinforcing immune system:
A hope to decelerate the COVID-19 pandemic
#MMPMID32773257
Kulyar MF
; Li R
; Mehmood K
; Waqas M
; Li K
; Li J
Phytomedicine
2021[May]; 85
(?): 153277
PMID32773257
show ga
The world is witnessing a difficult time. The race of developing a new
coronavirus (COVID-19) vaccine is becoming more urgent. Many preliminary studies
on the pathophysiology of COVID-19 patients have provided some clues to treat
this pandemic. However, no suitable treatment has found yet. Various symptoms of
patients infected with COVID-19 indicated the importance of immune regulation in
the human body. Severe cases admitted to the intensive care unit showed high
level of pro-inflammatory cytokines which enhanced the disease severity. Acute
Respiratory Distress Syndrome (ARDS) in COVID-19 patients is another critical
factor of disease severity and mortality. So, Immune modulation is the only way
of regulating immune system. Nigella sativa has been used for medicinal purposes
for centuries. The components of this plant are known for its intense
immune-regulatory, anti-inflammatory, and antioxidant benefits in obstructive
respiratory disorders. A molecular docking study also gave evidences that N.
sativa decelerates COVID-19 and might give the same or better results than the
FDA approved drugs. The aim of this review was to investigate the possible
immune-regulatory effects of N. sativa on COVID-19 pandemic. Our review found N.
sativa's Thymoquinone, Nigellidine, and ?-hederin can be a potential influencer
in reinforcing the immune response on molecular grounds.
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