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2020 ; 15
(11
): 1767-1772
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Atypical Skin Manifestations During Immune Checkpoint Blockage in Coronavirus
Disease 2019-Infected Patients With Lung Cancer
#MMPMID32653627
Rolfo C
; Cardona AF
; Ruiz-Patiño A
; Ariza S
; Zatarain-Barron L
; Pino LE
; Viola L
; Russo A
; Rojas L
; Ricaurte L
; Arrieta O
J Thorac Oncol
2020[Nov]; 15
(11
): 1767-1772
PMID32653627
show ga
A new coronavirus, named severe acute respiratory syndrome-coronavirus-2 by the
WHO, has rapidly spread around the world since its first reported case in late
December of 2019 from Wuhan, the People's Republic of China. As of mid-April
2020, this virus has affected more than 180 countries and territories, infecting
more than 1,650,000 individuals and causing over 100,000 deaths. With
approximately 20 million new cases globally per year, cancer affects a
substantial portion of the population. Individuals affected by cancer are more
susceptible to infections owing to coexisting chronic diseases (cardiovascular,
pulmonary, and diabetes), overall poor health status, and systemic
immunosuppressive states caused by both cancer and the anticancer treatment. As a
consequence, patients with malignancies, especially those with lung cancer who
develop coronavirus disease 2019, experience more difficult outcomes. A recent
multicenter study carried out by the Hubei Anti-Cancer Association has also
documented that patients with lung cancer had an increased risk of death,
intensive care unit requirement, risk of presenting severe or critical symptoms,
and use of invasive mechanical ventilation. Here, we present two representative
cases of patients with lung cancer and coronavirus disease 2019 without
respiratory compromise and with atypical and severe skin manifestations-findings
that could be influenced by the long-term use of anti-programmed cell death
protein 1 antibody.