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10.1038/s41375-020-0959-x

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suck abstract from ncbi


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pmid32647324
      Leukemia 2020 ; 34 (9 ): 2354-2363
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  • COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus #MMPMID32647324
  • Scarfò L ; Chatzikonstantinou T ; Rigolin GM ; Quaresmini G ; Motta M ; Vitale C ; Garcia-Marco JA ; Hernández-Rivas JÁ ; Mirás F ; Baile M ; Marquet J ; Niemann CU ; Reda G ; Munir T ; Gimeno E ; Marchetti M ; Quaglia FM ; Varettoni M ; Delgado J ; Iyengar S ; Janssens A ; Marasca R ; Ferrari A ; Cuéllar-García C ; Itchaki G ; ?pa?ek M ; De Paoli L ; Laurenti L ; Levin MD ; Lista E ; Mauro FR ; ?imkovi? M ; Van Der Spek E ; Vandenberghe E ; Trentin L ; Wasik-Szczepanek E ; Ruchlemer R ; Bron D ; De Paolis MR ; Del Poeta G ; Farina L ; Foglietta M ; Gentile M ; Herishanu Y ; Herold T ; Jaksic O ; Kater AP ; Kersting S ; Malerba L ; Orsucci L ; Popov VM ; Sportoletti P ; Yassin M ; Pocali B ; Barna G ; Chiarenza A ; Dos Santos G ; Nikitin E ; Andres M ; Dimou M ; Doubek M ; Enrico A ; Hakobyan Y ; Kalashnikova O ; Ortiz Pareja M ; Papaioannou M ; Rossi D ; Shah N ; Shrestha A ; Stanca O ; Stavroyianni N ; Strugov V ; Tam C ; Zdrenghea M ; Coscia M ; Stamatopoulos K ; Rossi G ; Rambaldi A ; Montserrat E ; Foà R ; Cuneo A ; Ghia P
  • Leukemia 2020[Sep]; 34 (9 ): 2354-2363 PMID32647324 show ga
  • Chronic lymphocytic leukemia (CLL) is a disease of the elderly, characterized by immunodeficiency. Hence, patients with CLL might be considered more susceptible to severe complications from COVID-19. We undertook this retrospective international multicenter study to characterize the course of COVID-19 in patients with CLL and identify potential predictors of outcome. Of 190 patients with CLL and confirmed COVID-19 diagnosed between 28/03/2020 and 22/05/2020, 151 (79%) presented with severe COVID-19 (need of oxygen and/or intensive care admission). Severe COVID-19 was associated with more advanced age (?65 years) (odds ratio 3.72 [95% CI 1.79-7.71]). Only 60 patients (39.7%) with severe COVID-19 were receiving or had recent (?12 months) treatment for CLL at the time of COVID-19 versus 30/39 (76.9%) patients with mild disease. Hospitalization rate for severe COVID-19 was lower (p?
  • |*Betacoronavirus [MESH]
  • |Adenine/analogs & derivatives [MESH]
  • |Age Factors [MESH]
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Antineoplastic Agents/pharmacology/therapeutic use [MESH]
  • |COVID-19 [MESH]
  • |Comorbidity [MESH]
  • |Coronavirus Infections/diagnosis/mortality/*pathology [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Leukemia, Lymphocytic, Chronic, B-Cell/*complications/drug therapy [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Pandemics [MESH]
  • |Piperidines [MESH]
  • |Pneumonia, Viral/diagnosis/mortality/*pathology [MESH]
  • |Prognosis [MESH]
  • |Protein Kinase Inhibitors/pharmacology/therapeutic use [MESH]
  • |Pyrazoles/pharmacology/therapeutic use [MESH]
  • |Pyrimidines/pharmacology/therapeutic use [MESH]
  • |Retrospective Studies [MESH]
  • |SARS-CoV-2 [MESH]
  • |Severity of Illness Index [MESH]


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