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2020 ; 34
(9
): 2354-2363
Nephropedia Template TP
gab.com Text
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English Wikipedia
COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a
joint study by ERIC, the European Research Initiative on CLL, and CLL Campus
#MMPMID32647324
Scarfò L
; Chatzikonstantinou T
; Rigolin GM
; Quaresmini G
; Motta M
; Vitale C
; Garcia-Marco JA
; Hernández-Rivas JÁ
; Mirás F
; Baile M
; Marquet J
; Niemann CU
; Reda G
; Munir T
; Gimeno E
; Marchetti M
; Quaglia FM
; Varettoni M
; Delgado J
; Iyengar S
; Janssens A
; Marasca R
; Ferrari A
; Cuéllar-García C
; Itchaki G
; ?pa?ek M
; De Paoli L
; Laurenti L
; Levin MD
; Lista E
; Mauro FR
; ?imkovi? M
; Van Der Spek E
; Vandenberghe E
; Trentin L
; Wasik-Szczepanek E
; Ruchlemer R
; Bron D
; De Paolis MR
; Del Poeta G
; Farina L
; Foglietta M
; Gentile M
; Herishanu Y
; Herold T
; Jaksic O
; Kater AP
; Kersting S
; Malerba L
; Orsucci L
; Popov VM
; Sportoletti P
; Yassin M
; Pocali B
; Barna G
; Chiarenza A
; Dos Santos G
; Nikitin E
; Andres M
; Dimou M
; Doubek M
; Enrico A
; Hakobyan Y
; Kalashnikova O
; Ortiz Pareja M
; Papaioannou M
; Rossi D
; Shah N
; Shrestha A
; Stanca O
; Stavroyianni N
; Strugov V
; Tam C
; Zdrenghea M
; Coscia M
; Stamatopoulos K
; Rossi G
; Rambaldi A
; Montserrat E
; Foà R
; Cuneo A
; Ghia P
Leukemia
2020[Sep]; 34
(9
): 2354-2363
PMID32647324
show ga
Chronic lymphocytic leukemia (CLL) is a disease of the elderly, characterized by
immunodeficiency. Hence, patients with CLL might be considered more susceptible
to severe complications from COVID-19. We undertook this retrospective
international multicenter study to characterize the course of COVID-19 in
patients with CLL and identify potential predictors of outcome. Of 190 patients
with CLL and confirmed COVID-19 diagnosed between 28/03/2020 and 22/05/2020, 151
(79%) presented with severe COVID-19 (need of oxygen and/or intensive care
admission). Severe COVID-19 was associated with more advanced age (?65 years)
(odds ratio 3.72 [95% CI 1.79-7.71]). Only 60 patients (39.7%) with severe
COVID-19 were receiving or had recent (?12 months) treatment for CLL at the time
of COVID-19 versus 30/39 (76.9%) patients with mild disease. Hospitalization rate
for severe COVID-19 was lower (p?0.05) for patients on ibrutinib versus those
on other regimens or off treatment. Of 151 patients with severe disease, 55
(36.4%) succumbed versus only 1/38 (2.6%) with mild disease; age and
comorbidities did not impact on mortality. In CLL, (1) COVID-19 severity
increases with age; (2) antileukemic treatment (particularly BTK inhibitors)
appears to exert a protective effect; (3) age and comorbidities did not impact on
mortality, alluding to a relevant role of CLL and immunodeficiency.
|*Betacoronavirus
[MESH]
|Adenine/analogs & derivatives
[MESH]
|Age Factors
[MESH]
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|Antineoplastic Agents/pharmacology/therapeutic use
[MESH]