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2021 ; 49
(2
): 158-165
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gab.com Text
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Clinical characteristics, outcomes and prognosticators in adult patients
hospitalized with COVID-19
#MMPMID32652252
Gavin W
; Campbell E
; Zaidi SA
; Gavin N
; Dbeibo L
; Beeler C
; Kuebler K
; Abdel-Rahman A
; Luetkemeyer M
; Kara A
Am J Infect Control
2021[Feb]; 49
(2
): 158-165
PMID32652252
show ga
BACKGROUND: COVID-19 is a novel disease caused by SARS-CoV-2. METHODS: We
conducted a retrospective evaluation of patients admitted with COVID-19 to one
site in March 2020. Patients were stratified into 3 groups: survivors who did not
receive mechanical ventilation (MV), survivors who received MV, and those who
received MV and died during hospitalization. RESULTS: There were 140
hospitalizations; 22 deaths (mortality rate 15.7%), 83 (59%) survived and did not
receive MV, 35 (25%) received MV and survived; 18 (12.9%) received MV and died.
Thee mean age of each group was 57.8, 55.8 and 72.7 years, respectively
(P?=?.0001). Of those who received MV and died, 61% were male (P = .01). More
than half the patients (n?=?90, 64%) were African American. First measured
d-dimer >575.5 ng/mL, procalcitonin > 0.24 ng/mL, lactate dehydrogenase >445.6
units/L, and brain natriuretic peptide (BNP) >104.75 pg/mL had odds ratios of
10.5, 5, 4.5 and 2.9, respectively for MV (P < .05 for all). Peak BNP >167.5
pg/mL had an odds ratio of 6.7 for inpatient mortality when mechanically
ventilated (P = .02). CONCLUSIONS: Age and gender may impact outcomes in
COVID-19. D-dimer, procalcitonin, lactate dehydrogenase and BNP may serve as
early indicators of disease trajectory.