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Isolation and characterization of an exopolymer produced by Bacillus
licheniformis: In vitro antiviral activity against enveloped viruses
#MMPMID32919551
Sánchez-León E
; Bello-Morales R
; López-Guerrero JA
; Poveda A
; Jiménez-Barbero J
; Gironès N
; Abrusci C
Carbohydr Polym
2020[Nov]; 248
(?): 116737
PMID32919551
show ga
The exopolymer (EPSp) produced by the strain B. licheniformis IDN-EC was isolated
and characterized using different techniques (MALDI-TOF, NMR, ATR-FTIR, TGA, DSC,
SEM). The results showed that the low molecular weight EPSp contained a long
polyglutamic acid and an extracellular teichoic acid polysaccharide. The latter
was composed of poly(glycerol phosphate) and was substituted at the 2-position of
the glycerol residues with a ?Gal and ?GlcNH(2). The ?Gal O-6 position was also
found to be substituted by a phosphate group. The antiviral capability of this
EPSp was also tested on both enveloped (herpesviruses HSV, PRV and vesicular
stomatitis VSV) and non-enveloped (MVM) viruses. The EPSp was efficient at
inhibiting viral entry for the herpesviruses and VSV but was not effective
against non-enveloped viruses. The in vivo assay of the EPSp in mice showed no
signs of toxicity which could allow for its application in the healthcare sector.
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