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10.1016/j.heares.2020.108019 http://scihub22266oqcxt.onion/10.1016/j.heares.2020.108019 C7345387!7345387!32768772     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hear+Res 2020 ; 395 (ä): 108019 Nephropedia Template TP {{tp|p=32768772|t=2020. Chloroquine kills hair cells in zebrafish lateral line and murine cochlear cultures: Implications for ototoxicity |pdf=|usr=}}{{32768772}} gab.com Text Chloroquine kills hair cells in zebrafish lateral line and murine cochlear cultures: Implications for ototoxicity JO: Hear Res http://www.kidney.de/pget.php?&tw=1&pmid=32768772 #FOAvip Hearing and balance deficits have been reported during and following treatment with the antimalarial drug chloroquine. However, experimental work examining the direct actions of chloroquine on mechanoreceptive hair cells in common experimental models is lacking. This study examines the effects of chloroquine on hair cells using two common experimental models: the zebrafish lateral line and neonatal mouse cochlear cultures. Zebrafish larvae were exposed to varying concentrations of chloroquine phosphate or hydroxychloroquine for 1 h or 24 h, and hair cells assessed by antibody staining. A significant, dose-dependent reduction in the number of surviving hair cells was seen across conditions for both exposure periods. Hydroxychloroquine showed similar toxicity. In mouse cochlear cultures, chloroquine damage was specific to outer hair cells in tissue from the cochlear basal turn, consistent with susceptibility to other ototoxic agents. These findings suggest a need for future studies employing hearing and balance monitoring during exposure to chloroquine and related compounds, particularly with interest in these compounds as therapeutics against viral infections including coronavirus. Twit Text FOAVip Chloroquine kills hair cells in zebrafish lateral line and murine cochlear cultures: Implications for ototoxicity ????Hear Res http://www.kidney.de/pget.php?&tw=1&pmid=32768772 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32768772 #FOAvip English Wikipedia <ref>{{Cite pmid|32768772}}</ref> Chloroquine kills hair cells in zebrafish lateral line and murine cochlear cultures: Implications for ototoxicity #MMPMID32768772 Davis SN; Wu P; Camci ED; Simon JA; Rubel EW; Raible DW Hear Res 2020[Sep]; 395 (ä): 108019 PMID32768772show ga Hearing and balance deficits have been reported during and following treatment with the antimalarial drug chloroquine. However, experimental work examining the direct actions of chloroquine on mechanoreceptive hair cells in common experimental models is lacking. This study examines the effects of chloroquine on hair cells using two common experimental models: the zebrafish lateral line and neonatal mouse cochlear cultures. Zebrafish larvae were exposed to varying concentrations of chloroquine phosphate or hydroxychloroquine for 1 h or 24 h, and hair cells assessed by antibody staining. A significant, dose-dependent reduction in the number of surviving hair cells was seen across conditions for both exposure periods. Hydroxychloroquine showed similar toxicity. In mouse cochlear cultures, chloroquine damage was specific to outer hair cells in tissue from the cochlear basal turn, consistent with susceptibility to other ototoxic agents. These findings suggest a need for future studies employing hearing and balance monitoring during exposure to chloroquine and related compounds, particularly with interest in these compounds as therapeutics against viral infections including coronavirus. äChloroquine kills hair cells in zebrafish lateral line and murine coch(epmc).pdf DeepDyve Pubget Overpricing