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2020 ; 9
(6
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Phytochemical Compositions and Biological Activities of Essential Oils from the
Leaves, Rhizomes and Whole Plant of Hornstedtia bella ?korni?k
#MMPMID32570731
Donadu MG
; Trong Le N
; Viet Ho D
; Quoc Doan T
; Tuan Le A
; Raal A
; Usai M
; Marchetti M
; Sanna G
; Madeddu S
; Rappelli P
; Diaz N
; Molicotti P
; Carta A
; Piras S
; Usai D
; Thi Nguyen H
; Cappuccinelli P
; Zanetti S
Antibiotics (Basel)
2020[Jun]; 9
(6
): ä PMID32570731
show ga
The rapid emergence of drug-resistant strains and novel viruses have motivated
the search for new anti-infectious agents. In this study, the chemical
compositions and cytotoxicity, as well as the antibacterial, antifungal,
antitrichomonas, and antiviral activities of essential oils from the leaves,
rhizomes, and whole plant of Hornstedtia bella were investigated. The GC/MS
analysis showed that ?-pinene, E-?-caryophyllene, and ?-humulene were found at
high concentrations in the essential oils. The essential oils exhibited (i)
inhibition against Staphylococcus aureus, methicillin-resistant Staphylococcus
aureus, Staphylococcus epidermidis with minimum inhibitory concentrations (MIC)
and minimum lethal concentration (MLC) values from 1 to 4% (v/v); (ii) MIC and
MLC values from 2 to 16% (v/v) in Candida tropicalis and Candida parapsilosis;
(iii) MIC and MLC values from 4 to 16% in Enterococcus faecalis; and (iv) MIC and
MLC values from 8 to greater than or equal to 16% (v/v) in the remaining strains,
including Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae,
Candida albicans, and Candida glabrata. In antitrichomonas activity, the leaves
and whole-plant oils of Hornstedtia bella possessed IC(50), IC(90), and MLC
values of 0.008%, 0.016%, and 0.03% (v/v), respectively, whilst those of rhizomes
oil had in turn, 0.004%, 0.008%, and 0.016% (v/v).Besides, the leaf oil showed a
weak cytotoxicity against Vero 76 and MRC-5; meanwhile, rhizomes and whole-plant
oils did not exert any toxic effects on cell monolayers. Finally, these oils were
not active against EV-A71.