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2020 ; 15
(1
): 165
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SARS-CoV-2 prevalence in an asymptomatic cancer cohort - results and consequences
for clinical routine
#MMPMID32646505
Marschner S
; Corradini S
; Rauch J
; Zacharias R
; Sujic A
; Mayerle J
; Petru R
; Grabein B
; Keppler OT
; Boelke E
; Belka C
; Niyazi M
Radiat Oncol
2020[Jul]; 15
(1
): 165
PMID32646505
show ga
BACKGROUND: Starting in December 2019, the current pandemic caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) confronts the world with an
unprecedented challenge. With no vaccine or drug being currently available to
control the pandemic spread, prevention and PCR (Polymerase chain reaction)
testing becomes a crucial pillar of medical systems. Aim of the present study was
to report on the first results of the measures taken in a large German Department
of Radiation Oncology, including PCR testing of asymptomatic cancer patients.
METHODS: Pandemic-adapted hygiene regulations and prevention measures for
patients and staff were implemented. A visiting ban on both wards was implemented
from the beginning and medical staff and patients were required to wear face
masks at all times. The waiting rooms were rearranged to ensure distance between
patients of at least 1.5?m. Clinical follow up was mainly done by telephone and
all patients had to complete a questionnaire regarding symptoms and contacts with
COVID-19 patients before entering our department. Educational documents were
created for patients to raise awareness of symptoms and avoidance strategies for
interactions with other people. Indications for therapy and fractionation schemes
were adapted when possible. In a subsequent step, all new asymptomatic patients
were tested via nasopharyngeal swab at our screening station shortly before their
simulation CT. RESULTS: All these measures and implementations have been well
accepted semiquantitatively measured by the consent received from patients and
staff. Regarding the PCR testing, only 1 out of 139 asymptomatic patients of our
cohort so far tested positive for SARS-CoV-2, reflecting a prevalence of 0.72% in
this cancer patient population. Up to this point no staff members was tested
positive. The start of the treatment for the PCR-positive patient was deferred
for 2 weeks. CONCLUSION: Due to the pandemic-adapted implementations, our
department seems well prepared during this crisis. The initial screening helps to
identify asymptomatic COVID-19 patients in order to protect other patients and
our staff from infection and the observed PCR prevalence is in line with
comparable studies. A regular PCR testing (e.g. twice a week) of all patients and
staff would in principle be desirable but is limited due to testing capacities at
present.
|*Betacoronavirus
[MESH]
|Adult
[MESH]
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|COVID-19
[MESH]
|Carrier State
[MESH]
|Cohort Studies
[MESH]
|Coronavirus Infections/diagnosis/*epidemiology/prevention & control
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Male
[MESH]
|Middle Aged
[MESH]
|Neoplasms/*virology
[MESH]
|Pandemics/prevention & control
[MESH]
|Pneumonia, Viral/diagnosis/*epidemiology/prevention & control
[MESH]
free
free
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