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2020 ; 477
(3
): 359-372
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Pulmonary pathology and COVID-19: lessons from autopsy The experience of
European Pulmonary Pathologists
#MMPMID32642842
Calabrese F
; Pezzuto F
; Fortarezza F
; Hofman P
; Kern I
; Panizo A
; von der Thüsen J
; Timofeev S
; Gorkiewicz G
; Lunardi F
Virchows Arch
2020[Sep]; 477
(3
): 359-372
PMID32642842
show ga
Since its initial recognition in December 2019, Coronavirus disease 19 (COVID-19)
has quickly spread to a pandemic infectious disease. The causative agent has been
recognized as a novel coronavirus, severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2), primarily affecting the respiratory tract. To date, no vaccines
are available nor any specific treatment. To limit the number of infections,
strict directives have been issued by governments that have been translated into
equally rigorous guidelines notably for post-mortem examinations by international
and national scientific societies. The recommendations for biosafety control
required during specimen collection and handling have strongly limited the
practice of autopsies of the COVID-19 patients to a few adequate laboratories. A
full pathological examination has always been considered an important tool to
better understand the pathophysiology of diseases, especially when the knowledge
of an emerging disorder is limited and the impact on the healthcare system is
significant. The first evidence of diffuse alveolar damage in the context of an
acute respiratory distress syndrome has now been joined by the latest findings
that report a more complex scenario in COVID-19, including a vascular involvement
and a wide spectrum of associated pathologies. Ancillary tools such as electron
microscopy and molecular biology used on autoptic tissue samples from autopsy are
also significantly contributing to confirm and/or identify new aspects useful for
a deeper knowledge of the pathogenetic mechanisms. This article will review and
summarize the pathological findings described in COVID-19 until now, chiefly
focusing on the respiratory tract, highlighting the importance of autopsy towards
a better knowledge of this disease.