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2020 ; 41
(9
): 2317-2324
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Neurological diseases as mortality predictive factors for patients with COVID-19:
a retrospective cohort study
#MMPMID32643133
Hwang JM
; Kim JH
; Park JS
; Chang MC
; Park D
Neurol Sci
2020[Sep]; 41
(9
): 2317-2324
PMID32643133
show ga
INTRODUCTION: In the current study, we evaluated factors that increase the
coronavirus disease (COVID-19) patient death rate by analyzing the data from two
cohort hospitals. In addition, we studied whether underlying neurological
diseases are risk factors for death. METHODS: In this retrospective cohort study,
we included 103 adult inpatients (aged ??18 years). We evaluated differences in
demographic data between surviving and non-surviving COVID-19 patients. RESULTS:
In a multivariate logistic analysis, age and the presence of chronic lung disease
and Alzheimer's dementia (AD) were the only significant parameters for predicting
COVID-19 non-survival (p?0.05). However, hypertension, coronary vascular
disease, dyslipidemia, chronic kidney disease, diabetes, and history of taking
angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme (ACE)
inhibitors, as well as nonsteroidal anti-inflammatory drugs (NSAIDs), were not
significantly associated with the death of COVID-19 patients. The optimal cutoff
value obtained from the maximum Youden index was 70 (sensitivity, 80.77%;
specificity, 61.04%), and the odds ratio of non-survival increased 1.055 fold for
every year of age. CONCLUSIONS: Clinicians should closely monitor and manage the
symptoms of COVID-19 patients who are over the age of 70 years or have chronic
lung disease or AD.