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2020 ; 44
(ä): 102353
Nephropedia Template TP
gab.com Text
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Management of Idiopathic CNS inflammatory diseases during the COVID-19 pandemic:
Perspectives and strategies for continuity of care from a South East Asian Center
with limited resources
#MMPMID32653804
Viswanathan S
Mult Scler Relat Disord
2020[Sep]; 44
(ä): 102353
PMID32653804
show ga
The Covid-19 pandemic poses a grave health management challenge globally of
unprecedented nature. Management of idiopathic Central Nervous system
inflammatory disorders (iCNSID) such as Multiple sclerosis, Neuromyelitis optica
and its spectrum disorders and related conditions during this pandemic needs to
be addressed with affirmative and sustainable strategies in order to prevent
disease related risks, medication related complications and possible COVID-19
disease associated effects. Global international iCNSIDs agencies and recent
publications are attempting to address this but such guidance is not available in
South East Asia. Here we outline prospectively qualitatively and quantitatively
novel strategies at a tertiary center in Malaysia catering for neuroimmunological
disorders despite modest resources during this pandemic. In this retrospective
study with longitudinal follow-up, we describe stratification of patients for
face to face versus virtual visits in the absence of formal teleneurology,
stratification of patients for treatment according to disease activity,
rescheduling, deferring initiation or extending treatment intervals of certain
disease modifying therapies(DMT's) or immunosuppressants(IS), especially those
producing lymphocyte depletion in MS and the continuation of IS in patients with
NMO/NMOSD. Furthermore, we highlight the use off-label treatments such as
Intravenous immunoglobulins/rituximab,bridging interferons/Teriflunomide
temporarily replacing more potent DMT choices,supply challenges of IS/DMT's and
tailoring blood watches and neuroimaging surveillance based on the current health
needs to stave off the pandemic and prevent at risk patients with iCNSID/health
care workers from possibly being exposed to the COVID-19.