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2020 ; 9
(3
): 669-675
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English Wikipedia
Povidone-Iodine Demonstrates Rapid In Vitro Virucidal Activity Against
SARS-CoV-2, The Virus Causing COVID-19 Disease
#MMPMID32643111
Anderson DE
; Sivalingam V
; Kang AEZ
; Ananthanarayanan A
; Arumugam H
; Jenkins TM
; Hadjiat Y
; Eggers M
Infect Dis Ther
2020[Sep]; 9
(3
): 669-675
PMID32643111
show ga
INTRODUCTION: As of 22 June 2020, Severe Acute Respiratory Syndrome
(SARS)-coronavirus (CoV)-2 has infected more than 8.95 million people worldwide,
causing?>?468,000 deaths. The virus is transmitted through respiratory droplets
and physical contact from contaminated surfaces to the mucosa. Hand hygiene and
oral decontamination among other measures are key to preventing the spread of the
virus. We report the in vitro virucidal activity of topical and oral
povidone-iodine (PVP-I) products against SARS-CoV-2. METHODS: Suspension assays
were used to assess the virucidal activity of PVP-I against SARS-CoV-2. Products
were tested at a contact time of 30 s for virucidal activity. Viral titres were
calculated using the Spearman-Kärber method and reported as median tissue culture
infectious dose (TCID(50))/mL. RESULTS: All four products [antiseptic solution
(PVP-I 10%), skin cleanser (PVP-I 7.5%), gargle and mouth wash (PVP-I 1%) and
throat spray (PVP-I 0.45%)] achieved???99.99% virucidal activity against
SARS-CoV-2, corresponding to???4 log(10) reduction of virus titre, within 30 s of
contact. CONCLUSION: This study provides evidence of rapid and effective
virucidal activity of PVP-I against SARS-CoV-2. PVP-I-based products are widely
available for medical and personal use for hand hygiene and oral decontamination,
and could be readily integrated into coronavirus disease, COVID-19, infection
control measures in hospital and community settings.