Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32685221
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Case+Rep+Nephrol
2020 ; 2020
(ä): 8811931
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19
(Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and
Renin-Angiotensin System Blockade
#MMPMID32685221
Chenna A
; Konala VM
; Bose S
; Roy S
; Madhira BR
; Gayam V
; Naramala S
; Adapa S
Case Rep Nephrol
2020[]; 2020
(ä): 8811931
PMID32685221
show ga
The renin-angiotensin system plays a very critical role in hypertension,
diabetes, and kidney and heart diseases. The blockade of the renin-angiotensin
system results in the prevention of progression of renal and cardiac damage.
There have been controversial hypotheses raised regarding the safety of
angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in
COVID-19 (coronavirus disease 2019). We present the case series of four patients
(2 men and 2 women; 1 Caucasian and 3 African Americans; two survived and two
died) with confirmed COVID-19, presenting with respiratory symptoms and acute
kidney injury, who have been on angiotensin-converting enzyme inhibitors or
angiotensin receptor blockers. Membrane-bound angiotensin-converting enzyme 2
(ACE2) has been implicated as the gateway for viral entry into the human cell in
causing the infection. The factors contributing to acute kidney injury are
diuretics, iodinated contrast administration, hemodynamic instability apart from
ACE inhibitors, and angiotensin receptor blockers. The ACE inhibitors and ARBs
were stopped in these patients due to acute kidney injury. We also discussed the
role of ACE2 and the renin-angiotensin system (RAS) blockade in patients with
COVID-19 infection along with pathogenesis.