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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Inflammopharmacology
2020 ; 28
(5
): 1219-1222
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A viral infection explanation for Kawasaki disease in general and for COVID-19
virus-related Kawasaki disease symptoms
#MMPMID32638151
Roe K
Inflammopharmacology
2020[Oct]; 28
(5
): 1219-1222
PMID32638151
show ga
SARS-CoV-2, a new virus that appeared in Wuhan, China, in 2019 has approximately
an 80% genomic match to the Severe Acute Respiratory Symptom (SARS) virus, which
is known to come from a bat virus. Symptoms of Kawasaki disease in general and
incomplete Kawasaki disease have been seen in a subset of pediatric patients
having a current or previous infection of SARS-CoV-2. A viral infection, such as
a SARS-CoV-2 virus infection, could result in extensive antigen-antibody immune
complexes that cannot be quickly cleared in a subset of patients and thus create
a type III hypersensitivity immune reaction and cause Kawasaki disease or
Kawasaki disease symptoms (also known as multisystem inflammatory syndrome) in a
subset of patients. Extensive binding of antibodies to viral antigens can create
antigen-antibody immune complexes, which, if not eliminated in certain
individuals having dysfunctional complement systems, can start inflammatory type
III hypersensitivity symptoms, including protease releases that can disrupt
epithelium, mesothelium, and endothelium basement membranes, and induce pervasive
inflammation throughout the body. This could continue after SARS-CoV-2 infections
end if the first wave of protease attacks on basement membranes created new
secondary autoantibodies and new uncleared antigen-antibody immune complexes.
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