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10.1016/j.jcrc.2020.07.002 http://scihub22266oqcxt.onion/10.1016/j.jcrc.2020.07.002 C7340597!7340597 !32674001     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32674001 &cmd=llinks): Failed to open stream: HTTP request failed! 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Late histopathologic characteristics of critically ill COVID-19 patients: Different phenotypes without evidence of invasive aspergillosis, a case series |pdf=|usr=}}{{32674001 }} gab.com Text Late histopathologic characteristics of critically ill COVID-19 patients: Different phenotypes without evidence of invasive aspergillosis, a case series JO: J Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=32674001 #FOAvip PURPOSE: Pathological data of critical ill COVID-19 patients is essential in the search for optimal treatment options. MATERIAL AND METHODS: We performed postmortem needle core lung biopsies in seven patients with COVID-19 related ARDS. Clinical, radiological and microbiological characteristics are reported together with histopathological findings. MEASUREMENT AND MAIN RESULTS: Patients age ranged from 58 to 83 years, five males and two females were included. Time from hospital admission to death ranged from 12 to 36 days, with a mean of 20 ventilated days. ICU stay was complicated by pulmonary embolism in five patients and positive galactomannan on bronchoalveolar lavage fluid in six patients, suggesting COVID-19 associated pulmonary aspergillosis. Chest CT in all patients showed ground glass opacities, commonly progressing to nondependent consolidations. We observed four distinct histopathological patterns: acute fibrinous and organizing pneumonia, diffuse alveolar damage, fibrosis and, in four out of seven patients an organizing pneumonia. None of the biopsy specimens showed any signs of invasive aspergillosis. CONCLUSIONS: In this case series common late histopathology in critically ill COVID patients is not classic DAD but heterogeneous with predominant pattern of organizing pneumonia. Postmortem biopsy investigations in critically COVID-19 patients with probable COVID-19 associated pulmonary aspergillosis obtained no evidence for invasive aspergillosis. Twit Text FOAVip Late histopathologic characteristics of critically ill COVID-19 patients: Different phenotypes without evidence of invasive aspergillosis, a case series ????J Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=32674001 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32674001 #FOAvip English Wikipedia <ref>{{Cite pmid|32674001 }}</ref> Late histopathologic characteristics of critically ill COVID-19 patients: Different phenotypes without evidence of invasive aspergillosis, a case series #MMPMID32674001 Flikweert AW ; Grootenboers MJJH ; Yick DCY ; du Mée AWF ; van der Meer NJM ; Rettig TCD ; Kant MKM J Crit Care 2020[Oct]; 59 (ä): 149-155 PMID32674001 show ga PURPOSE: Pathological data of critical ill COVID-19 patients is essential in the search for optimal treatment options. MATERIAL AND METHODS: We performed postmortem needle core lung biopsies in seven patients with COVID-19 related ARDS. Clinical, radiological and microbiological characteristics are reported together with histopathological findings. MEASUREMENT AND MAIN RESULTS: Patients age ranged from 58 to 83 years, five males and two females were included. Time from hospital admission to death ranged from 12 to 36 days, with a mean of 20 ventilated days. ICU stay was complicated by pulmonary embolism in five patients and positive galactomannan on bronchoalveolar lavage fluid in six patients, suggesting COVID-19 associated pulmonary aspergillosis. Chest CT in all patients showed ground glass opacities, commonly progressing to nondependent consolidations. We observed four distinct histopathological patterns: acute fibrinous and organizing pneumonia, diffuse alveolar damage, fibrosis and, in four out of seven patients an organizing pneumonia. None of the biopsy specimens showed any signs of invasive aspergillosis. CONCLUSIONS: In this case series common late histopathology in critically ill COVID patients is not classic DAD but heterogeneous with predominant pattern of organizing pneumonia. Postmortem biopsy investigations in critically COVID-19 patients with probable COVID-19 associated pulmonary aspergillosis obtained no evidence for invasive aspergillosis. |Aged [MESH] |Aged, 80 and over [MESH] |Autopsy [MESH] |Betacoronavirus [MESH] |Biopsy [MESH] |Biopsy, Large-Core Needle [MESH] |Bronchoalveolar Lavage Fluid/chemistry [MESH] |COVID-19 [MESH] |Coinfection [MESH] |Coronavirus Infections/complications/diagnostic imaging/*pathology [MESH] |Critical Illness [MESH] |Female [MESH] |Galactose/analogs & derivatives [MESH] |Humans [MESH] |Lung Diseases, Interstitial/diagnostic imaging/etiology/*pathology [MESH] |Lung/diagnostic imaging/*pathology [MESH] |Male [MESH] |Mannans/metabolism [MESH] |Middle Aged [MESH] |Pandemics [MESH] |Phenotype [MESH] |Pneumonia, Viral/complications/diagnostic imaging/*pathology [MESH] |Pulmonary Aspergillosis/complications/diagnostic imaging/*pathology [MESH] |Pulmonary Embolism/complications/diagnostic imaging [MESH] |Respiratory Distress Syndrome/diagnostic imaging/etiology/*pathology [MESH] |SARS-CoV-2 [MESH]Late histopathologic characteristics of critically ill COVID-19 patien(epmc).pdf DeepDyve Pubget Overpricing