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2020 ; 14
(5
): 1133-1142
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Association of hypertension, diabetes, stroke, cancer, kidney disease, and
high-cholesterol with COVID-19 disease severity and fatality: A systematic
review
#MMPMID32663789
Zaki N
; Alashwal H
; Ibrahim S
Diabetes Metab Syndr
2020[Sep]; 14
(5
): 1133-1142
PMID32663789
show ga
BACKGROUND AND AIMS: To undertake a review and critical appraisal of
published/preprint reports that offer methods of determining the effects of
hypertension, diabetes, stroke, cancer, kidney issues, and high-cholesterol on
COVID-19 disease severity. METHODS: A search was conducted by two authors
independently on the freely available COVID-19 Open Research Dataset (CORD-19).
We developed an automated search engine to screen a total of 59,000 articles in a
few seconds. Filtering of the articles was then undertaken using keywords and
questions, e.g. "Effects of diabetes on COVID/normal
coronavirus/SARS-CoV-2/nCoV/COVID-19 disease severity, mortality?". The search
terms were repeated for all the comorbidities considered in this paper.
Additional articles were retrieved by searching via Google Scholar and PubMed.
FINDINGS: A total of 54 articles were considered for a full review. It was
observed that diabetes, hypertension, and cholesterol levels possess an apparent
relation to COVID-19 severity. Other comorbidities, such as cancer, kidney
disease, and stroke, must be further evaluated to determine a strong relationship
to the virus. CONCLUSION: Reports associating cancer, kidney disease, and stroke
with COVID-19 should be carefully interpreted, not only because of the size of
the samples, but also because patients could be old, have a history of smoking,
or have any other clinical condition suggesting that these factors might be
associated with the poor COVID-19 outcomes rather than the comorbidity itself.
Further research regarding this relationship and its clinical management is
warranted.