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A review for natural polysaccharides with anti-pulmonary fibrosis properties,
which may benefit to patients infected by 2019-nCoV
#MMPMID32829859
Chen RR
; Li YJ
; Chen JJ
; Lu CL
Carbohydr Polym
2020[Nov]; 247
(?): 116740
PMID32829859
show ga
Pulmonary fibrosis (PF) is a lung disease with highly heterogeneous and mortality
rate, but its therapeutic options are now still limited. Corona virus disease
2019 (COVID-19) has been characterized by WHO as a pandemic, and the global
number of confirmed COVID-19 cases has been more than 8.0 million. It is strongly
supported for that PF should be one of the major complications in COVID-19
patients by the evidences of epidemiology, viral immunology and current clinical
researches. The anti-PF properties of naturally occurring polysaccharides have
attracted increasing attention in last two decades, but is still lack of a
comprehensively understanding. In present review, the resources, structural
features, anti-PF activities, and underlying mechanisms of these polysaccharides
are summarized and analyzed, which was expected to provide a scientific evidence
supporting the application of polysaccharides for preventing or treating PF in
COVID-19 patients.
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