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10.1038/s41467-020-17292-4 http://scihub22266oqcxt.onion/10.1038/s41467-020-17292-4 C7338513!7338513 !32632085     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32632085 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2020 ; 11 (1 ): 3434 Nephropedia Template TP {{tp|p=32632085 |t=2020. Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia |pdf=|usr=}}{{32632085 }} gab.com Text Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32632085 #FOAvip The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia are urgently required. Here we show that, compared with healthy controls, COVID-19 patients' T cell compartment displays several alterations involving naïve, central memory, effector memory and terminally differentiated cells, as well as regulatory T cells and PD1(+)CD57(+) exhausted T cells. Significant alterations exist also in several lineage-specifying transcription factors and chemokine receptors. Terminally differentiated T cells from patients proliferate less than those from healthy controls, whereas their mitochondria functionality is similar in CD4(+) T cells from both groups. Patients display significant increases of proinflammatory or anti-inflammatory cytokines, including T helper type-1 and type-2 cytokines, chemokines and galectins; their lymphocytes produce more tumor necrosis factor (TNF), interferon-?, interleukin (IL)-2 and IL-17, with the last observation implying that blocking IL-17 could provide a novel therapeutic strategy for COVID-19. Twit Text FOAVip Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32632085 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32632085 #FOAvip English Wikipedia <ref>{{Cite pmid|32632085 }}</ref> Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia #MMPMID32632085 De Biasi S ; Meschiari M ; Gibellini L ; Bellinazzi C ; Borella R ; Fidanza L ; Gozzi L ; Iannone A ; Lo Tartaro D ; Mattioli M ; Paolini A ; Menozzi M ; Mili? J ; Franceschi G ; Fantini R ; Tonelli R ; Sita M ; Sarti M ; Trenti T ; Brugioni L ; Cicchetti L ; Facchinetti F ; Pietrangelo A ; Clini E ; Girardis M ; Guaraldi G ; Mussini C ; Cossarizza A Nat Commun 2020[Jul]; 11 (1 ): 3434 PMID32632085 show ga The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia are urgently required. Here we show that, compared with healthy controls, COVID-19 patients' T cell compartment displays several alterations involving naïve, central memory, effector memory and terminally differentiated cells, as well as regulatory T cells and PD1(+)CD57(+) exhausted T cells. Significant alterations exist also in several lineage-specifying transcription factors and chemokine receptors. Terminally differentiated T cells from patients proliferate less than those from healthy controls, whereas their mitochondria functionality is similar in CD4(+) T cells from both groups. Patients display significant increases of proinflammatory or anti-inflammatory cytokines, including T helper type-1 and type-2 cytokines, chemokines and galectins; their lymphocytes produce more tumor necrosis factor (TNF), interferon-?, interleukin (IL)-2 and IL-17, with the last observation implying that blocking IL-17 could provide a novel therapeutic strategy for COVID-19. |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Betacoronavirus/*immunology [MESH] |Biomarkers/metabolism [MESH] |CD4-Positive T-Lymphocytes/*immunology/metabolism/pathology [MESH] |CD8-Positive T-Lymphocytes/*immunology/metabolism/pathology [MESH] |COVID-19 [MESH] |Cellular Senescence [MESH] |Coronavirus Infections/blood/*immunology/pathology [MESH] |Cytokine Release Syndrome [MESH] |Cytokines/immunology/metabolism [MESH] |Female [MESH] |Humans [MESH] |Immunologic Memory [MESH] |Italy/epidemiology [MESH] |Lymphocyte Activation [MESH] |Lymphocyte Count [MESH] |Male [MESH] |Middle Aged [MESH] |Pandemics [MESH] |Pneumonia, Viral/blood/*immunology/pathology [MESH] |SARS-CoV-2 [MESH] |T-Lymphocyte Subsets/*immunology/metabolism/pathology [MESH]Marked T cell activation, senescence, exhaustion and skewing towards T(epmc).pdf DeepDyve Pubget Overpricing