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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Korean+Med+Sci
2020 ; 35
(26
): e243
Nephropedia Template TP
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The Correlation of Comorbidities on the Mortality in Patients with COVID-19: an
Observational Study Based on the Korean National Health Insurance Big Data
#MMPMID32627443
Kim DW
; Byeon KH
; Kim J
; Cho KD
; Lee N
J Korean Med Sci
2020[Jul]; 35
(26
): e243
PMID32627443
show ga
BACKGROUND: Mortality of coronavirus disease 2019 (COVID-19) is a major concern
for quarantine departments in all countries. This is because the mortality of
infectious diseases determines the basic policy stance of measures to prevent
infectious diseases. Early screening of high-risk groups and taking action are
the basics of disease management. This study examined the correlation of
comorbidities on the mortality of patients with COVID-19. METHODS: We constructed
epidemiologic characteristics and medical history database based on the Korean
National Health Insurance Service Big Data and linked COVID-19 registry data of
Korea Centers for Disease Control & Prevention (KCDC) for this emergent
observational cohort study. A total of 9,148 patients with confirmed COVID-19
were included. Mortalities by sex, age, district, income level and all range of
comorbidities classified by International Classification of Diseases-10 based 298
categories were estimated. RESULTS: There were 3,556 male confirmed cases, 67
deaths, and crude death rate (CDR) of 1.88%. There were 5,592 females, 63 deaths,
and CDR of 1.13%. The most confirmed cases were 1,352 patients between the ages
of 20 to 24, followed by 25 to 29. As a result of multivariate logistic
regression analysis that adjusted epidemiologic factors to view the risk of
death, the odds ratio of death would be hemorrhagic conditions and other diseases
of blood and blood-forming organs 3.88-fold (95% confidence interval [CI],
1.52-9.88), heart failure 3.17-fold (95% CI, 1.88-5.34), renal failure 3.07-fold
(95% CI, 1.43-6.61), prostate malignant neoplasm 2.88-fold (95% CI, 1.01-8.22),
acute myocardial infarction 2.38-fold (95% CI, 1.03-5.49), diabetes was 1.82-fold
(95% CI, 1.25-2.67), and other ischemic heart disease 1.71-fold (95% CI,
1.09-2.66). CONCLUSION: We hope that this study could provide information on high
risk groups for preemptive interventions. In the future, if a vaccine for
COVID-19 is developed, it is expected that this study will be the basic data for
recommending immunization by selecting those with chronic disease that had high
risk of death, as recommended target diseases for vaccination.