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2020 ; 7
(7
): ofaa252
Nephropedia Template TP
gab.com Text
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English Wikipedia
The Clinical and Radiological Manifestations in Coronavirus Disease 2019 With
Negative Nucleic Acid Results
#MMPMID32704513
Lang G
; Su J
; Wu W
; Zhao H
; Ying S
; Lou H
; Shen X
; Yin MT
; Xu K
; Liu J
; Ren C
; Sheng J
Open Forum Infect Dis
2020[Jul]; 7
(7
): ofaa252
PMID32704513
show ga
BACKGROUND: Coronavirus disease 2019 (COVID-19) was a new emerging disease with
high infectiousness. Its diagnosis primarily depended on real-time polymerase
chain reaction (RT-PCR) results. This study investigated epidemiological,
clinical, and radiological characteristics of COVID-19 with negative RT-PCR
results before confirmation. METHODS: Patients with COVID-19 were enrolled and
divided into 2 groups: a negative group with negative RT-PCR results before
confirmation and a positive group with positive results at the first detection.
Epidemiological and clinical features were compared. Dynamic chest computerized
tomography (CT) images of the negative group were evaluated. RESULTS: Ninety-nine
laboratory-confirmed patients with COVID-19 including 8 patients (8%) with
negative RT-PCR results were included. Patients from the negative group had
similar epidemiological features: the average age (50.25?±?13.27 years in the
negative group and 53.70?±?16.64 years in the positive group) and gender
distribution (males made up 50% of the negative group and 62.6% of the positive
group) were comparable. No significant differences were observed in clinical
symptoms between the 2 groups. We found that fever was the most common symptom
for both groups, followed by cough, expectoration, chest distress, fatigue, and
gastroenterological symptoms. Moreover, ground-glass opacities and consolidations
were the main manifestation in chest CT of patients with COVID-19 with or without
confirmed RT-PCR results. CONCLUSIONS: Regardless of initial RT-PCR results,
patients with COVID-19 had similar epidemiological, clinical, and chest CT
features. Our study suggests value from early chest CT scans in COVID-19
screening and dynamic significance of radiology in disease monitoring should
guide clinical decisions.
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