Serum Iron Level as a Potential Predictor of Coronavirus Disease 2019 Severity
and Mortality: A Retrospective Study
#MMPMID32661499
Zhao K
; Huang J
; Dai D
; Feng Y
; Liu L
; Nie S
Open Forum Infect Dis
2020[Jul]; 7
(7
): ofaa250
PMID32661499
show ga
BACKGROUND: Various types of pulmonary diseases are associated with iron
deficiency. However, information on iron status in coronavirus disease 2019
(COVID-19) is scarce. METHODS: This study included 50 hospitalized patients with
confirmed COVID-19. The role of serum iron in predicting severity and mortality
of COVID-19 was evaluated. RESULTS: The most common symptoms of COVID-19 patients
in this study were cough (82%), fever (64%), and chest distress (42%). Of the 50
patients, 45 (90%) patients had abnormally low serum iron levels (<7.8 ?mol/L).
The severity of COVID-19 was negatively correlated with serum iron levels before
and after treatment and was positively correlated with C-reactive protein, serum
amyloid A, D-dimer, lactate dehydrogenase, urea nitrogen, and myoglobin levels.
Decreased serum iron level could predict the transition of COVID-19 from mild to
severe and critical illness. Seven (53.8%) patients with a lower serum iron level
after treatment in the critical group had died. There was a significant
difference in posttreatment serum iron levels between COVID-19 survivors and
nonsurvivors. CONCLUSIONS: Serum iron deficiency was detected in the patients
with COVID-19. The severity and mortality of the disease was closely correlated
with serum iron levels. Low serum iron concentration was an independent risk
factor for death in COVID-19 patients.
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