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10.1093/emph/eoaa021 http://scihub22266oqcxt.onion/10.1093/emph/eoaa021 C7337683!7337683!32974030     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32974030&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Evol+Med+Public+Health 2020 ; 2020 (1): 109-13 Nephropedia Template TP {{tp|p=32974030|t=2020. Lions, tigers and kittens too: ACE2 and susceptibility to COVID-19 |pdf=|usr=}}{{32974030}} gab.com Text Lions, tigers and kittens too: ACE2 and susceptibility to COVID-19 JO: Evol Med Public Health http://www.kidney.de/pget.php?&tw=1&pmid=32974030 #FOAvip SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2) has been reported to infect domesticated animals in a species-specific manner, where cats were susceptible but not dogs. Using the recently published crystal structure of the SARS-CoV-2 spike protein complexed with the human host cell receptor angiotensin converting enzyme 2 (ACE2), we characterized the structure and evolution of ACE2 in several of these species and identify a single interacting amino acid residue conserved between human and Felidae ACE2 but not in Canidae that correlates with virus susceptibility. Using computational analyses we describe how this site likely affects ACE2 targeting by the virus. Thus, we highlight how evolution-based approaches can be used to form hypotheses and study animal transmission of such viruses in the future. Twit Text FOAVip Lions, tigers and kittens too: ACE2 and susceptibility to COVID-19 ????Evol Med Public Health http://www.kidney.de/pget.php?&tw=1&pmid=32974030 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32974030 #FOAvip English Wikipedia <ref>{{Cite pmid|32974030}}</ref> Lions, tigers and kittens too: ACE2 and susceptibility to COVID-19 #MMPMID32974030 Mathavarajah S; Dellaire G Evol Med Public Health 2020[]; 2020 (1): 109-13 PMID32974030show ga SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2) has been reported to infect domesticated animals in a species-specific manner, where cats were susceptible but not dogs. Using the recently published crystal structure of the SARS-CoV-2 spike protein complexed with the human host cell receptor angiotensin converting enzyme 2 (ACE2), we characterized the structure and evolution of ACE2 in several of these species and identify a single interacting amino acid residue conserved between human and Felidae ACE2 but not in Canidae that correlates with virus susceptibility. Using computational analyses we describe how this site likely affects ACE2 targeting by the virus. Thus, we highlight how evolution-based approaches can be used to form hypotheses and study animal transmission of such viruses in the future. äLions, tigers and kittens too: ACE2 and susceptibility to COVID-19 (epmc).pdf DeepDyve Pubget Overpricing