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10.1093/ckj/sfaa084

http://scihub22266oqcxt.onion/10.1093/ckj/sfaa084
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C7337639!7337639!32695323
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suck abstract from ncbi


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pmid32695323      Clin+Kidney+J 2020 ; 13 (3): 334-9
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  • SARS-CoV-2 infection in dialysis patients in northern Italy: a single-centre experience #MMPMID32695323
  • Fontana F; Giaroni F; Frisina M; Alfano G; Mori G; Lucchi L; Magistroni R; Cappelli G
  • Clin Kidney J 2020[Jun]; 13 (3): 334-9 PMID32695323show ga
  • Background: Dialysis patients are considered at high risk for COVID-19 and the infection can easily spread in dialysis units. Methods: We conducted an observational single-centre cohort study to describe clinical characteristics, treatments and outcomes of dialysis patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We tested patients who presented symptoms or had contact with a confirmed case. We enrolled 15 patients positive for SARS-CoV-2. Results: We tested 37 of 306 dialysis patients. Patients with SARS-CoV-2 infection were older (mean age 75.96?±?11.09?years) and all had comorbidities. At presentation, most had interstitial infiltrates on chest X-ray, three-quarters had leucopenia and none had respiratory insufficiency. During follow-up, there was an increase in serum C-reactive protein and interleukin-6. Eighty percent of patients received supplemental oxygen; none received non-invasive ventilation, one was intubated. Most patients (80%) were treated with oral hydroxychloroquine for a median time of 6.5?days [interquartile range (IQR) 5?14.5] and 40% received azithromycin; two patients received a short course of antivirals and one received a single dose of tocilizumab. Only two patients did not require hospitalization. Of the nine survivors, eight still tested positive for SARS-CoV-2 a median of 19?days (IQR 9.25?23) after diagnosis. Six patients died (case fatality rate 40%) a median of 5.5?days (IQR 1.75?9.75) after diagnosis. The main reported cause of death was respiratory failure related to COVID-19 (five patients). Conclusions: We report a single-centre experience of SARS-CoV-2 infection in dialysis patients. The disease showed a high case fatality rate and most patients required hospitalization. Survivors show prolonged viral shedding.
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