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10.1007/s11845-020-02291-7

http://scihub22266oqcxt.onion/10.1007/s11845-020-02291-7
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suck abstract from ncbi


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pmid32627127
      Ir+J+Med+Sci 2021 ; 190 (1 ): 403-409
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  • Clinical guidance for navigating the QTc-prolonging and arrhythmogenic potential of pharmacotherapy during the COVID-19 pandemic #MMPMID32627127
  • Carron J ; Sharif Z ; Hussein H ; Kennedy M ; McAdam B ; Sheahan R
  • Ir J Med Sci 2021[Feb]; 190 (1 ): 403-409 PMID32627127 show ga
  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for coronavirus disease 19 (COVID-19), has rapidly spread since December 2019 to become the focus of healthcare systems worldwide. Its highly contagious nature and significant mortality has led to its prioritization as a public health issue. The race to prevent and treat this disease has led to "off-label" prescribing of medications such as hydroxychloroquine, azithromycin, and Kaletra (lopinavir/ritonavir). Currently, there is no robust clinical evidence for the use of these drugs in the treatment of COVID-19, with most, if not all of these medications associated with the potential for QT interval prolongation, torsades de pointes, and resultant drug-induced sudden cardiac death. The aim of this document is to help healthcare providers mitigate the potential deleterious effects of drug-induced QTc prolongation.
  • |*COVID-19 Drug Treatment [MESH]
  • |Anti-Bacterial Agents/*adverse effects [MESH]
  • |Antiviral Agents/*adverse effects [MESH]
  • |Azithromycin/*adverse effects [MESH]
  • |Drug Combinations [MESH]
  • |Electrocardiography [MESH]
  • |Enzyme Inhibitors/adverse effects [MESH]
  • |Humans [MESH]
  • |Hydroxychloroquine/*adverse effects [MESH]
  • |Long QT Syndrome/blood/*chemically induced/diagnosis/prevention & control [MESH]
  • |Lopinavir/*adverse effects [MESH]
  • |Magnesium/blood [MESH]
  • |Pandemics [MESH]
  • |Potassium/blood [MESH]
  • |Practice Guidelines as Topic [MESH]
  • |Risk Assessment [MESH]
  • |Risk Factors [MESH]
  • |Ritonavir/*adverse effects [MESH]
  • |SARS-CoV-2 [MESH]


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