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2021 ; 190
(1
): 403-409
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Clinical guidance for navigating the QTc-prolonging and arrhythmogenic potential
of pharmacotherapy during the COVID-19 pandemic
#MMPMID32627127
Carron J
; Sharif Z
; Hussein H
; Kennedy M
; McAdam B
; Sheahan R
Ir J Med Sci
2021[Feb]; 190
(1
): 403-409
PMID32627127
show ga
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for
coronavirus disease 19 (COVID-19), has rapidly spread since December 2019 to
become the focus of healthcare systems worldwide. Its highly contagious nature
and significant mortality has led to its prioritization as a public health issue.
The race to prevent and treat this disease has led to "off-label" prescribing of
medications such as hydroxychloroquine, azithromycin, and Kaletra
(lopinavir/ritonavir). Currently, there is no robust clinical evidence for the
use of these drugs in the treatment of COVID-19, with most, if not all of these
medications associated with the potential for QT interval prolongation, torsades
de pointes, and resultant drug-induced sudden cardiac death. The aim of this
document is to help healthcare providers mitigate the potential deleterious
effects of drug-induced QTc prolongation.
|*COVID-19 Drug Treatment
[MESH]
|Anti-Bacterial Agents/*adverse effects
[MESH]
|Antiviral Agents/*adverse effects
[MESH]
|Azithromycin/*adverse effects
[MESH]
|Drug Combinations
[MESH]
|Electrocardiography
[MESH]
|Enzyme Inhibitors/adverse effects
[MESH]
|Humans
[MESH]
|Hydroxychloroquine/*adverse effects
[MESH]
|Long QT Syndrome/blood/*chemically induced/diagnosis/prevention & control
[MESH]