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10.1053/j.ackd.2020.07.002

http://scihub22266oqcxt.onion/10.1053/j.ackd.2020.07.002
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C7334971!7334971!33308506
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suck abstract from ncbi


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pmid33308506      Adv+Chronic+Kidney+Dis 2020 ; 27 (5): 404-11
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  • Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System #MMPMID33308506
  • Edmonston DL; South AM; Sparks MA; Cohen JB
  • Adv Chronic Kidney Dis 2020[Sep]; 27 (5): 404-11 PMID33308506show ga
  • Hypertension emerged from early reports as a potential risk factor for worse outcomes for persons with coronavirus disease 2019 (COVID-19). Among the putative links between hypertension and COVID-19 is a key counter-regulatory component of the renin-angiotensin system (RAS): angiotensin-converting enzyme 2 (ACE2). ACE2 facilitates entry of severe acute respiratory syndrome coronavirus 2, the virus responsible for COVID-19, into host cells. Because RAS inhibitors have been suggested to increase ACE2 expression, health-care providers and patients have grappled with the decision of whether to discontinue these medications during the COVID-19 pandemic. However, experimental models of analogous viral pneumonias suggest RAS inhibitors may exert protective effects against acute lung injury. We review how RAS and ACE2 biology may affect outcomes in COVID-19 through pulmonary and other systemic effects. In addition, we briefly detail the data for and against continuation of RAS inhibitors in persons with COVID-19 and summarize the current consensus recommendations from select specialty organizations.
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