Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32768974
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Biomed+Pharmacother
2020 ; 129
(ä): 110499
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Outbreak of COVID-19: An emerging global pandemic threat
#MMPMID32768974
Peng M
Biomed Pharmacother
2020[Sep]; 129
(ä): 110499
PMID32768974
show ga
Since the first outbreak of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection in Wuhan, Hubei, China in December 2019, it is now
recognized as a pandemic by the World Health Organization (WHO) as more than 200
countries and territories worldwide are affected with an increasing incidence.
The SARS-CoV-2 infection results in a spectrum of non-specific signs and
symptoms, ranging from asymptomatic infection, to flu-like illness such as fever,
cough, dry cough and fatigue, to pneumonia, acute respiratory distress syndrome,
and even multi-organ failures with high morbidity and mortality. SARS-CoV-2 is
mainly transmitted through respiratory droplets that infected people exhale
during incubation and onset period. By 12 June 2020, over 7.5 million confirmed
cases of Coronavirus disease 2019 (COVID-19) with more than 421,000 deaths in the
world have been reported to the WHO. No specific medication is approved to treat
COVID-19, raising the urgent need for antiviral drug development. By 12 June
2020, there are over 1000 clinical trials registered in clinicaltrials.gov for
treatment of COVID-19. This review summarizes the epidemiology, virology,
clinical presentation, pathophysiology, diagnosis, and particularly the antiviral
drugs currently under clinical trials for treatment of SARS-CoV-2 infection,
together with the challenges and perspectives of this disease are also discussed.