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Decreased prealbumin level is associated with increased risk for mortality in
elderly hospitalized patients with COVID-19
#MMPMID32854020
Zuo P
; Tong S
; Yan Q
; Cheng L
; Li Y
; Song K
; Chen Y
; Dai Y
; Gao H
; Zhang C
Nutrition
2020[Oct]; 78
(?): 110930
PMID32854020
show ga
OBJECTIVES: High-risk patients ?65 y of age with coronavirus disease 2019
(COVID-19) tended to have lower serum prealbumin concentrations. The aim of this
study was to investigate the association of prealbumin at baseline on
COVID-19-related mortality in elderly patients (?65 y of age). METHODS: We
non-selectively and consecutively collected participants from Tongji Hospital in
Wuhan from January 17 to February 17, 2020. Univariate and multivariate logistic
regression models were employed to evaluate the correlation between prealbumin
and in-hospital outcomes (in-hospital mortality, admission to the intensive care
unit [ICU], and mechanical ventilation) in elderly patients with COVID-19. Linear
trend was performed by entering the median value of each category of prealbumin
tertile as a continuous variable and was visually confirmed by using generalized
additive models. Interaction and stratified analyses were conducted as well.
RESULTS: We included 446 elderly patients with COVID-19 in the final analyses.
In-hospital mortality was 14.79%. Of the 446 patients, 15.47% were admitted to
the ICU and 21.3% required mechanical ventilation. Compared with patients in the
highest tertile, the prealbumin of patients in the lowest tertile had a
19.09-fold higher risk for death [odds ratio (OR), 20.09; 95% confidence interval
(CI), 3.62-111.64; P = 0.0006], 25.39-fold higher risk for ICU admission (OR,
26.39; 95% CI, 4.04-172.39; P = 0.0006), and 1.8-fold higher risk for mechanical
ventilation (OR, 2.8; 95% CI, 1.15-6.78; P = 0.0227) after adjustment for
potential confounders. There was a linear trend correlation between serum
prealbumin concentration and risk for in-hospital mortality, ICU admission, and
mechanical ventilation in elderly patients with COVID-19 infection. CONCLUSION:
Prealbumin is an independent risk factor of in-hospital mortality for elderly
patients with COVID-19. Assessment of prealbumin may help identify high-risk
individuals ?65 y of age with COVID-19.
|*Betacoronavirus
[MESH]
|*Hospital Mortality
[MESH]
|Aged
[MESH]
|Biomarkers/blood
[MESH]
|COVID-19
[MESH]
|China/epidemiology
[MESH]
|Coronavirus Infections/*blood/*mortality
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Intensive Care Units/statistics & numerical data
[MESH]
|Logistic Models
[MESH]
|Male
[MESH]
|Multivariate Analysis
[MESH]
|Odds Ratio
[MESH]
|Pandemics
[MESH]
|Pneumonia, Viral/*blood/*mortality
[MESH]
|Prealbumin/*analysis
[MESH]
|Respiration, Artificial/statistics & numerical data
[MESH]
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