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10.1007/s11684-020-0800-y http://scihub22266oqcxt.onion/10.1007/s11684-020-0800-y C7333369!7333369 !32621202     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32621202 &cmd=llinks): Failed to open stream: HTTP request failed! 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Use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in context of COVID-19 outbreak: a retrospective analysis |pdf=|usr=}}{{32621202 }} gab.com Text Use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in context of COVID-19 outbreak: a retrospective analysis JO: Front Med http://www.kidney.de/pget.php?&tw=1&pmid=32621202 #FOAvip The possible effects of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) on COVID-19 disease severity have generated considerable debate. We performed a single-center, retrospective analysis of hospitalized adult COVID-19 patients in Wuhan, China, who had definite clinical outcome (dead or discharged) by February 15, 2020. Patients on anti-hypertensive treatment with or without ACEI/ARB were compared on their clinical characteristics and outcomes. The medical records from 702 patients were screened. Among the 101 patients with a history of hypertension and taking at least one anti-hypertensive medication, 40 patients were receiving ACEI/ARB as part of their regimen, and 61 patients were on antihypertensive medication other than ACEI/ARB. We observed no statistically significant differences in percentages of in-hospital mortality (28% vs. 34%, P = 0.46), ICU admission (20% vs. 28%, P = 0.37) or invasive mechanical ventilation (18% vs. 26%, P = 0.31) between patients with or without ACEI/ARB treatment. Further multivariable adjustment of age and gender did not provide evidence for a significant association between ACEI/ARB treatment and severe COVID-19 outcomes. Our findings confirm the lack of an association between chronic receipt of renin-angiotensin system antagonists and severe outcomes of COVID-19. Patients should continue previous anti-hypertensive therapy until further evidence is available. Twit Text FOAVip Use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in context of COVID-19 outbreak: a retrospective analysis ????Front Med http://www.kidney.de/pget.php?&tw=1&pmid=32621202 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32621202 #FOAvip English Wikipedia <ref>{{Cite pmid|32621202 }}</ref> Use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in context of COVID-19 outbreak: a retrospective analysis #MMPMID32621202 Xu J ; Huang C ; Fan G ; Liu Z ; Shang L ; Zhou F ; Wang Y ; Yu J ; Yang L ; Xie K ; Huang Z ; Huang L ; Gu X ; Li H ; Zhang Y ; Wang Y ; Hayden FG ; Horby PW ; Cao B ; Wang C Front Med 2020[Oct]; 14 (5 ): 601-612 PMID32621202 show ga The possible effects of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) on COVID-19 disease severity have generated considerable debate. We performed a single-center, retrospective analysis of hospitalized adult COVID-19 patients in Wuhan, China, who had definite clinical outcome (dead or discharged) by February 15, 2020. Patients on anti-hypertensive treatment with or without ACEI/ARB were compared on their clinical characteristics and outcomes. The medical records from 702 patients were screened. Among the 101 patients with a history of hypertension and taking at least one anti-hypertensive medication, 40 patients were receiving ACEI/ARB as part of their regimen, and 61 patients were on antihypertensive medication other than ACEI/ARB. We observed no statistically significant differences in percentages of in-hospital mortality (28% vs. 34%, P = 0.46), ICU admission (20% vs. 28%, P = 0.37) or invasive mechanical ventilation (18% vs. 26%, P = 0.31) between patients with or without ACEI/ARB treatment. Further multivariable adjustment of age and gender did not provide evidence for a significant association between ACEI/ARB treatment and severe COVID-19 outcomes. Our findings confirm the lack of an association between chronic receipt of renin-angiotensin system antagonists and severe outcomes of COVID-19. Patients should continue previous anti-hypertensive therapy until further evidence is available. |*Betacoronavirus/drug effects/physiology [MESH] |*Coronavirus Infections/mortality/physiopathology/therapy [MESH] |*Pandemics [MESH] |*Pneumonia, Viral/mortality/physiopathology/therapy [MESH] |Angiotensin Receptor Antagonists/*therapeutic use [MESH] |Angiotensin-Converting Enzyme Inhibitors/*therapeutic use [MESH] |Antihypertensive Agents/therapeutic use [MESH] |COVID-19 [MESH] |China/epidemiology [MESH] |Comorbidity [MESH] |Female [MESH] |Hospital Mortality [MESH] |Humans [MESH] |Hypertension/*drug therapy/epidemiology [MESH] |Male [MESH] |Middle Aged [MESH] |Outcome and Process Assessment, Health Care [MESH] |Retrospective Studies [MESH] |SARS-CoV-2 [MESH]Use of angiotensin-converting enzyme inhibitors and angiotensin II rec(epmc).pdf DeepDyve Pubget Overpricing