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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Lancet+Infect+Dis
2020 ; 20
(11
): 1273-1280
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COVID-19 in health-care workers in three hospitals in the south of the
Netherlands: a cross-sectional study
#MMPMID32622380
Sikkema RS
; Pas SD
; Nieuwenhuijse DF
; O'Toole Á
; Verweij J
; van der Linden A
; Chestakova I
; Schapendonk C
; Pronk M
; Lexmond P
; Bestebroer T
; Overmars RJ
; van Nieuwkoop S
; van den Bijllaardt W
; Bentvelsen RG
; van Rijen MML
; Buiting AGM
; van Oudheusden AJG
; Diederen BM
; Bergmans AMC
; van der Eijk A
; Molenkamp R
; Rambaut A
; Timen A
; Kluytmans JAJW
; Oude Munnink BB
; Kluytmans van den Bergh MFQ
; Koopmans MPG
Lancet Infect Dis
2020[Nov]; 20
(11
): 1273-1280
PMID32622380
show ga
BACKGROUND: 10 days after the first reported case of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection in the Netherlands (on Feb 27,
2020), 55 (4%) of 1497 health-care workers in nine hospitals located in the south
of the Netherlands had tested positive for SARS-CoV-2 RNA. We aimed to gain
insight in possible sources of infection in health-care workers. METHODS: We did
a cross-sectional study at three of the nine hospitals located in the south of
the Netherlands. We screened health-care workers at the participating hospitals
for SARS-CoV-2 infection, based on clinical symptoms (fever or mild respiratory
symptoms) in the 10 days before screening. We obtained epidemiological data
through structured interviews with health-care workers and combined this
information with data from whole-genome sequencing of SARS-CoV-2 in clinical
samples taken from health-care workers and patients. We did an in-depth analysis
of sources and modes of transmission of SARS-CoV-2 in health-care workers and
patients. FINDINGS: Between March 2 and March 12, 2020, 1796 (15%) of 12?022
health-care workers were screened, of whom 96 (5%) tested positive for
SARS-CoV-2. We obtained complete and near-complete genome sequences from 50
health-care workers and ten patients. Most sequences were grouped in three
clusters, with two clusters showing local circulation within the region. The
noted patterns were consistent with multiple introductions into the hospitals
through community-acquired infections and local amplification in the community.
INTERPRETATION: Although direct transmission in the hospitals cannot be ruled
out, our data do not support widespread nosocomial transmission as the source of
infection in patients or health-care workers. FUNDING: EU Horizon 2020 (RECoVer,
VEO, and the European Joint Programme One Health METASTAVA), and the National
Institute of Allergy and Infectious Diseases, National Institutes of Health.