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2020 ; 56
(2
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gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Development of a clinical decision support system for severity risk prediction
and triage of COVID-19 patients at hospital admission: an international
multicentre study
#MMPMID32616597
Wu G
; Yang P
; Xie Y
; Woodruff HC
; Rao X
; Guiot J
; Frix AN
; Louis R
; Moutschen M
; Li J
; Li J
; Yan C
; Du D
; Zhao S
; Ding Y
; Liu B
; Sun W
; Albarello F
; D'Abramo A
; Schininà V
; Nicastri E
; Occhipinti M
; Barisione G
; Barisione E
; Halilaj I
; Lovinfosse P
; Wang X
; Wu J
; Lambin P
Eur Respir J
2020[Aug]; 56
(2
): ä PMID32616597
show ga
BACKGROUND: The outbreak of coronavirus disease 2019 (COVID-19) has globally
strained medical resources and caused significant mortality. OBJECTIVE: To
develop and validate a machine-learning model based on clinical features for
severity risk assessment and triage for COVID-19 patients at hospital admission.
METHOD: 725 patients were used to train and validate the model. This included a
retrospective cohort from Wuhan, China of 299 hospitalised COVID-19 patients from
23 December 2019 to 13 February 2020, and five cohorts with 426 patients from
eight centres in China, Italy and Belgium from 20 February 2020 to 21 March 2020.
The main outcome was the onset of severe or critical illness during
hospitalisation. Model performances were quantified using the area under the
receiver operating characteristic curve (AUC) and metrics derived from the
confusion matrix. RESULTS: In the retrospective cohort, the median age was
50?years and 137 (45.8%) were male. In the five test cohorts, the median age was
62?years and 236 (55.4%) were male. The model was prospectively validated on five
cohorts yielding AUCs ranging from 0.84 to 0.93, with accuracies ranging from
74.4% to 87.5%, sensitivities ranging from 75.0% to 96.9%, and specificities
ranging from 55.0% to 88.0%, most of which performed better than the pneumonia
severity index. The cut-off values of the low-, medium- and high-risk
probabilities were 0.21 and 0.80. The online calculators can be found at
www.covid19risk.ai. CONCLUSION: The machine-learning model, nomogram and online
calculator might be useful to access the onset of severe and critical illness
among COVID-19 patients and triage at hospital admission.