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10.1016/j.hrthm.2020.06.033 http://scihub22266oqcxt.onion/10.1016/j.hrthm.2020.06.033 C7328618!7328618 !32621881     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32621881 &cmd=llinks): Failed to open stream: HTTP request failed! 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Incidence of arrhythmias and electrocardiographic abnormalities in symptomatic pediatric patients with PCR-positive SARS-CoV-2 infection, including drug-induced changes in the corrected QT interval |pdf=|usr=}}{{32621881 }} gab.com Text Incidence of arrhythmias and electrocardiographic abnormalities in symptomatic pediatric patients with PCR-positive SARS-CoV-2 infection, including drug-induced changes in the corrected QT interval JO: Heart Rhythm http://www.kidney.de/pget.php?&tw=1&pmid=32621881 #FOAvip BACKGROUND: There is limited data regarding the electrophysiological abnormalities and arrhythmias in children with COVID-19, including those associated with treatment using potentially proarrhythmic hydroxychloroquine (HCQ) and azithromycin (AZN). OBJECTIVES: To describe the electrophysiologic findings and arrhythmias associated with pediatric COVID-19 and its treatment. METHODS: A single-center retrospective chart review was undertaken and included all patients with (1) symptoms of COVID-19 and (2) PCR-positive nasopharyngeal swabs for SARS-CoV-2 who were placed on continuous telemetry for the duration of their hospitalization during March through May, 2020. RESULTS: Thirty-six patients were included in the study. Significant arrhythmias were found in 6 (nonsustained ventricular tachycardia in 5 and sustained atrial tachycardia in 1). All were self-resolving and half prompted prophylactic antiarrhythmic therapy. Patients with significant arrhythmias were likely to have noncardiac comorbidities (4/6), but these were not more common than in patients without arrhythmias (20/30, P = 1). The use of HCQ was associated with statistically significant QTc prolongation (413 ± 19 ms vs 425 ± 16 ms, P =.005). QTc was not statistically different in patients with and without arrhythmias (425 ± 15 ms vs 425 ± 15 ms, P = 1). CONCLUSIONS: In pediatric patients with PCR-positive active COVID-19 infection, significant arrhythmias are infrequent, but are more common than expected in a general pediatric population. Comorbidities are not more common in patients with arrhythmias than in patients without arrhythmias. COVID-19 treatment using HCQ is associated with QTc prolongation but was not associated with arrhythmias in pediatric patients. Twit Text FOAVip Incidence of arrhythmias and electrocardiographic abnormalities in symptomatic pediatric patients with PCR-positive SARS-CoV-2 infection, including drug-induced changes in the corrected QT interval ????Heart Rhythm http://www.kidney.de/pget.php?&tw=1&pmid=32621881 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32621881 #FOAvip English Wikipedia <ref>{{Cite pmid|32621881 }}</ref> Incidence of arrhythmias and electrocardiographic abnormalities in symptomatic pediatric patients with PCR-positive SARS-CoV-2 infection, including drug-induced changes in the corrected QT interval #MMPMID32621881 Samuel S ; Friedman RA ; Sharma C ; Ganigara M ; Mitchell E ; Schleien C ; Blaufox AD Heart Rhythm 2020[Nov]; 17 (11 ): 1960-1966 PMID32621881 show ga BACKGROUND: There is limited data regarding the electrophysiological abnormalities and arrhythmias in children with COVID-19, including those associated with treatment using potentially proarrhythmic hydroxychloroquine (HCQ) and azithromycin (AZN). OBJECTIVES: To describe the electrophysiologic findings and arrhythmias associated with pediatric COVID-19 and its treatment. METHODS: A single-center retrospective chart review was undertaken and included all patients with (1) symptoms of COVID-19 and (2) PCR-positive nasopharyngeal swabs for SARS-CoV-2 who were placed on continuous telemetry for the duration of their hospitalization during March through May, 2020. RESULTS: Thirty-six patients were included in the study. Significant arrhythmias were found in 6 (nonsustained ventricular tachycardia in 5 and sustained atrial tachycardia in 1). All were self-resolving and half prompted prophylactic antiarrhythmic therapy. Patients with significant arrhythmias were likely to have noncardiac comorbidities (4/6), but these were not more common than in patients without arrhythmias (20/30, P = 1). The use of HCQ was associated with statistically significant QTc prolongation (413 ± 19 ms vs 425 ± 16 ms, P =.005). QTc was not statistically different in patients with and without arrhythmias (425 ± 15 ms vs 425 ± 15 ms, P = 1). CONCLUSIONS: In pediatric patients with PCR-positive active COVID-19 infection, significant arrhythmias are infrequent, but are more common than expected in a general pediatric population. Comorbidities are not more common in patients with arrhythmias than in patients without arrhythmias. COVID-19 treatment using HCQ is associated with QTc prolongation but was not associated with arrhythmias in pediatric patients. |*Arrhythmias, Cardiac/diagnosis/epidemiology [MESH] |*Azithromycin/administration & dosage/adverse effects [MESH] |*Coronavirus Infections/diagnosis/drug therapy/epidemiology/physiopathology [MESH] |*Electrocardiography/methods/statistics & numerical data [MESH] |*Hydroxychloroquine/administration & dosage/adverse effects [MESH] |*Long QT Syndrome/chemically induced/diagnosis [MESH] |*Pandemics [MESH] |*Pneumonia, Viral/diagnosis/drug therapy/epidemiology/physiopathology [MESH] |Anti-Infective Agents/administration & dosage/adverse effects [MESH] |Betacoronavirus/isolation & purification [MESH] |COVID-19 [MESH] |COVID-19 Testing [MESH] |Child [MESH] |Clinical Laboratory Techniques/methods [MESH] |Female [MESH] |Humans [MESH] |Incidence [MESH] |Male [MESH] |New York City/epidemiology [MESH] |Outcome and Process Assessment, Health Care [MESH] |Retrospective Studies [MESH] |Risk Factors [MESH]Incidence of arrhythmias and electrocardiographic abnormalities in sym(epmc).pdf DeepDyve Pubget Overpricing