Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32747157
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
A cytokine super cyclone in COVID-19 patients with risk factors: the therapeutic
potential of BCG immunization
#MMPMID32747157
Johnson BS
; Laloraya M
Cytokine Growth Factor Rev
2020[Aug]; 54
(?): 32-42
PMID32747157
show ga
The seventh human coronavirus SARS-CoV2 belongs to the cluster of extremely
pathogenic coronaviruses including SARS-CoV and MERS-CoV, which can cause fatal
lower respiratory tract infection. Likewise, SARS-CoV2 infection can be fatal as
the disease advances to pneumonia, followed by acute respiratory distress
syndrome (ARDS). The development of lethal clinical symptons is associated with
an exaggerated production of inflammatory cytokines, referred to as the cytokine
storm, is a consequence of a hyperactivated immune response aginst the infection.
In this article, we discuss the pathogenic consequences of the cytokine storm and
its relationship with COVID-19 associated risk factors. The increased
pro-inflammatory immune status in patients with risk factors (diabetes,
hypertension, cardiovascular disease, COPD) exacerbates the Cytokine-storm of
COVID-19 into a 'Cytokine Super Cyclone'. We also evaluate the antiviral immune
responses provided by BCG vaccination and the potential role of 'trained
immunity' in early protection against SARS-CoV2.
|Antiviral Agents/therapeutic use
[MESH]
|BCG Vaccine/*therapeutic use
[MESH]
|Betacoronavirus/immunology
[MESH]
|COVID-19
[MESH]
|Cardiovascular Diseases/pathology
[MESH]
|Coronavirus Infections/drug therapy/immunology/*prevention & control
[MESH]
|Cytokine Release Syndrome/immunology/pathology/*prevention & control
[MESH]
|Cytokines/*blood
[MESH]
|Diabetes Mellitus/pathology
[MESH]
|Humans
[MESH]
|Hypertension/pathology
[MESH]
|Middle East Respiratory Syndrome Coronavirus/immunology
[MESH]
|Mycobacterium bovis/immunology
[MESH]
|Pandemics/*prevention & control
[MESH]
|Pneumonia, Viral/drug therapy/immunology/*prevention & control
[MESH]
free
free
free
