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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Infect+Genet+Evol
2020 ; 84
(ä): 104440
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Ancestral origin, antigenic resemblance and epidemiological insights of novel
coronavirus (SARS-CoV-2): Global burden and Bangladesh perspective
#MMPMID32622082
Uddin MB
; Hasan M
; Harun-Al-Rashid A
; Ahsan MI
; Imran MAS
; Ahmed SSU
Infect Genet Evol
2020[Oct]; 84
(ä): 104440
PMID32622082
show ga
SARS-CoV-2, a new coronavirus strain responsible for COVID-19, has emerged in
Wuhan City, China, and continuing its global pandemic nature. The availability of
the complete gene sequences of the virus helps to know about the origin and
molecular characteristics of this virus. In the present study, we performed
bioinformatic analysis of the available gene sequence data of SARS-CoV-2 for the
understanding of evolution and molecular characteristics and immunogenic
resemblance of the circulating viruses. Phylogenetic analysis was performed for
four types of representative viral proteins (spike, membrane, envelope and
nucleoprotein) of SARS-CoV-2, HCoV-229E, HCoV-OC43, SARS-CoV, HCoV-NL63, HKU1,
MERS-CoV, HKU4, HKU5 and BufCoV-HKU26. The findings demonstrated that SARS-CoV-2
exhibited convergent evolutionary relation with previously reported SARS-CoV. It
was also depicted that SARS-CoV-2 proteins were highly similar and identical to
SARS-CoV proteins, though proteins from other coronaviruses showed a lower level
of resemblance. The cross-checked conservancy analysis of SARS-CoV-2 antigenic
epitopes showed significant conservancy with antigenic epitopes derived from
SARS-CoV. Descriptive epidemiological analysis on several epidemiological indices
was performed on available epidemiological outbreak information from several open
databases on COVID-19 (SARS-CoV-2). Satellite-derived imaging data have been
employed to understand the role of temperature in the environmental persistence
of the virus. Findings of the descriptive analysis were used to describe the
global impact of newly emerged SARS-CoV-2, and the risk of an epidemic in
Bangladesh.