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2020 ; 10
(11
): 2125-2139
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Novel agents targeting leukemia cells and immune microenvironment for prevention
and treatment of relapse of acute myeloid leukemia after allogeneic hematopoietic
stem cell transplantation
#MMPMID32837873
Shi W
; Jin W
; Xia L
; Hu Y
Acta Pharm Sin B
2020[Nov]; 10
(11
): 2125-2139
PMID32837873
show ga
Relapse remains the worst life-threatening complications after allogeneic
hematopoietic stem cell transplantation (allo-HSCT) in patients with acute
myeloid leukemia (AML), whose prognosis has been historically dismal. Given the
rapid development of genomics and immunotherapies, the interference strategies
for AML recurrence have been changing these years. More and more novel targeting
agents that have received the U.S. Food and Drug Administration (FDA) approval
for de novo AML treatment have been administrated in the salvage or maintenance
therapy of post-HSCT relapse. Targeted strategies that regulate the immune
microenvironment of and optimize the graft versus leukemia (GVL) effect of immune
cells are gradually improved. Such agents not only have been proven to achieve
clinical benefits from a single drug, but if combined with classic therapies, can
significantly improve the poor prognosis of AML patients who relapse after
allo-HSCT. This review will focus on currently available and promising upcoming
agents and also discuss the challenges and limitations of targeted therapies in
the allogeneic hematopoietic stem cell transplantation community.