The landscape of cognitive function in recovered COVID-19 patients
#MMPMID32912598
Zhou H
; Lu S
; Chen J
; Wei N
; Wang D
; Lyu H
; Shi C
; Hu S
J Psychiatr Res
2020[Oct]; 129
(?): 98-102
PMID32912598
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This study aims to evaluate the impacts of COVID-19 on cognitive functions in
recovered patients and its relationship with inflammatory profiles. Twenty-nine
patients recovered from COVID-19 as confirmed by negative nucleic tests for two
consecutive times were recruited. A total of 29 age-, gender- and
education-matched healthy controls were also recruited. The cognitive functions
of all subjects were evaluated by the iPad-based online neuropsychological tests,
including the Trail Making Test (TMT), Sign Coding Test (SCT), Continuous
Performance Test (CPT), and Digital Span Test (DST). Blood samples from all
patients were collected for examining inflammatory profiles, including
interleukin-2 (IL-2), IL-4, IL-6, IL-10, tumor necrosis factor-? (TNF-?),
interferon-? (IFN-?), and C-reactive protein (CRP). The relationship between
cognitive functions and inflammatory profiles were analyzed by Pearson
correlation. In results, although no significant differences were found in TMT,
SCT, and DST between the two groups, patients with COVID-19 scored lower in the
correct number of the second and third parts of CPT, they also scored higher in
the missing number of the third part of CPT (all P < 0.05). In patients with
COVID-19, there was a trend of significant difference for lower reaction time in
the first and second parts of CPT (P = 0.050, and 0.051, respectively), as well
as the lower correct number of the second part of CPT (P = 0.050). Correlation
analysis showed that the reaction time for the first and second parts of CPT was
positively correlated with the CRP levels (r = 0.557 and 0.410, P < 0.05). In
conclusion, our findings indicated that cognitive impairments exist even in
patients recovered from COVID-19, and might be possibly linked to the underlying
inflammatory processes.
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