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10.1016/j.xcrm.2020.100052 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2020.100052 C7323681!7323681!32835305     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2020 ; 1 (4): ä Nephropedia Template TP {{tp|p=32835305|t=2020. Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection |pdf=|usr=}}{{32835305}} gab.com Text Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=32835305 #FOAvip Coronavirus disease 2019 (COVID-19) is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is defined by respiratory symptoms, but cardiac complications including viral myocarditis are also prevalent. Although ischemic and inflammatory responses caused by COVID-19 can detrimentally affect cardiac function, the direct impact of SARS-CoV-2 infection on human cardiomyocytes is not well understood. Here, we utilize human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as a model to examine the mechanisms of cardiomyocyte-specific infection by SARS-CoV-2. Microscopy and RNA sequencing demonstrate that SARS-CoV-2 can enter hiPSC-CMs via ACE2. Viral replication and cytopathic effect induce hiPSC-CM apoptosis and cessation of beating after 72 h of infection. SARS-CoV-2 infection activates innate immune response and antiviral clearance gene pathways, while inhibiting metabolic pathways and suppressing ACE2 expression. These studies show that SARS-CoV-2 can infect hiPSC-CMs in vitro, establishing a model for elucidating infection mechanisms and potentially a cardiac-specific antiviral drug screening platform. Twit Text FOAVip Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=32835305 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32835305 #FOAvip English Wikipedia <ref>{{Cite pmid|32835305}}</ref> Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection #MMPMID32835305 Sharma A; Garcia G; Wang Y; Plummer JT; Morizono K; Arumugaswami V; Svendsen CN Cell Rep Med 2020[Jul]; 1 (4): ä PMID32835305show ga Coronavirus disease 2019 (COVID-19) is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is defined by respiratory symptoms, but cardiac complications including viral myocarditis are also prevalent. Although ischemic and inflammatory responses caused by COVID-19 can detrimentally affect cardiac function, the direct impact of SARS-CoV-2 infection on human cardiomyocytes is not well understood. Here, we utilize human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as a model to examine the mechanisms of cardiomyocyte-specific infection by SARS-CoV-2. Microscopy and RNA sequencing demonstrate that SARS-CoV-2 can enter hiPSC-CMs via ACE2. Viral replication and cytopathic effect induce hiPSC-CM apoptosis and cessation of beating after 72 h of infection. SARS-CoV-2 infection activates innate immune response and antiviral clearance gene pathways, while inhibiting metabolic pathways and suppressing ACE2 expression. These studies show that SARS-CoV-2 can infect hiPSC-CMs in vitro, establishing a model for elucidating infection mechanisms and potentially a cardiac-specific antiviral drug screening platform. äHuman iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infect(epmc).pdf DeepDyve Pubget Overpricing