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2020 ; 105
(4
): 476-483
Nephropedia Template TP
gab.com Text
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English Wikipedia
Regional outcomes of severe acute respiratory syndrome coronavirus 2 infection in
hospitalised patients with haematological malignancy
#MMPMID32544294
Booth S
; Willan J
; Wong H
; Khan D
; Farnell R
; Hunter A
; Eyre T
; Katz H
; Dungarwalla M
; Chen L
; Browning J
; Polzella P
; Gray N
; Neelakantan P
; Dhillon EK
; Dutton D
; Sternberg A
; Prideaux S
; Collins GP
; Peniket A
Eur J Haematol
2020[Oct]; 105
(4
): 476-483
PMID32544294
show ga
OBJECTIVES: We sought to characterise the outcomes of patients with
haematological malignancy and severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection in hospital in our regional network of 7 hospitals.
METHODS: Consecutive hospitalised patients with haematological malignancy and
SARS-CoV-2 infection were identified from 01/03/2020 to 06/05/2020. Outcomes were
categorised as death, resolved or ongoing. The primary outcome was preliminary
case fatality rate (pCFR), defined as the number of cases resulting in death as a
proportion of all diagnosed cases. Analysis was primarily descriptive. RESULTS:
66 Patients were included, overall pCFR was 51.5%. Patients ? 70 years accounted
for the majority of hospitalised cases (42, 63%) and fatalities (25, 74%).
Mortality was similar between females (52%) and males (51%). Immunosuppressive or
cytotoxic treatment within 3 months of the diagnosis of SARS-CoV-2 infection was
associated with a significantly higher pCFR of 70%, compared with 28% in those
not on active treatment (P = .0013, 2 proportions z test). CONCLUSIONS: Mortality
rates in patients with haematological malignancy and SARS-CoV-2 infection in
hospital are high supporting measures to minimise the risk of infection in this
population.
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|Antineoplastic Agents/adverse effects
[MESH]
|COVID-19/*complications/mortality/prevention & control
[MESH]
free
free
free
