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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Med+Virol
2020 ; 92
(11
): 2874-2879
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
A cross-sectional community-based observational study of asymptomatic SARS-CoV-2
prevalence in the greater Indianapolis area
#MMPMID32543722
Meyers KJ
; Jones ME
; Goetz IA
; Botros FT
; Knorr J
; Manner DH
; Woodward B
J Med Virol
2020[Nov]; 92
(11
): 2874-2879
PMID32543722
show ga
The Asymptomatic novel CORonavirus iNfection (ACORN) study was designed to
investigate the prevalence of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection in the asymptomatic adult population of the Indianapolis
metropolitan area, to follow individuals testing positive for the development of
symptoms, and to understand duration of positive test results. ACORN is a
cross-sectional community-based observational study of adult residents presenting
asymptomatic for COVID-like illness, defined as the self-reported absence of the
following three symptoms in the last 7 days: fever (?100°F), new-onset or
worsening cough, and new-onset or worsening shortness of breath. SARS-CoV-2
infection was determined by real-time reverse transcription-polymerase chain
reaction in nasopharyngeal swab samples. SARS-CoV-2 infection prevalence was
expressed as a point estimate with 95% confidence interval (CI). Test results are
reported for 2953 participants who enrolled and underwent nasopharyngeal swab
testing between 7 April 2020 and 16 May 2020. Among tested participants, 91
(3.1%; 95% CI: 2.5%-3.7%) were positive for SARS-CoV-2. Overall, baseline
characteristics, medical history, and infection risk factors were comparable
between SARS-CoV-2 positive and negative participants. Within the ongoing 14-day
follow-up period for positive participants, 58 (71.6%) of 81 assessed
participants remained asymptomatic while others (n?=?23, 28.4%) reported one or
more symptoms. Indiana had "Stay-at-Home" orders in place during nearly the
entire test period reported here, yet 3.1% of asymptomatic participants tested
positive for SARS-CoV-2. These results indicate screening questions had limited
predictive utility for testing in an asymptomatic population and suggest broader
testing strategies are needed. Importantly, these findings underscore that more
research is needed to understand the viral transmission and the role asymptomatic
and presymptomatic individuals play in this global pandemic.
|Adolescent
[MESH]
|Adult
[MESH]
|Aged
[MESH]
|Asymptomatic Infections/*epidemiology
[MESH]
|COVID-19 Nucleic Acid Testing/statistics & numerical data
[MESH]
|COVID-19/*epidemiology
[MESH]
|Cities/epidemiology
[MESH]
|Cough/epidemiology
[MESH]
|Cross-Sectional Studies
[MESH]
|Female
[MESH]
|Fever/epidemiology
[MESH]
|Humans
[MESH]
|Indiana/epidemiology
[MESH]
|Male
[MESH]
|Middle Aged
[MESH]
|Nasopharynx/*virology
[MESH]
|Prevalence
[MESH]
|Public Health/*statistics & numerical data
[MESH]